Networks for systems biology: conceptual connection of data and function
Networks for systems biology: conceptual connection of data and function
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DOI：
10.1049/iet-syb.2010.0025
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发表时间：
2011-05-01
影响因子：
2.3
通讯作者：
Dehmer, M.
中科院分区：
文献类型：
--
作者：
Emmert-Streib, F.;Dehmer, M.
本研究的目的是调查使用网络和基于网络的方法在系统生物学。本研究首先介绍了图论和基本措施，允许量化网络的结构特性。然后，作者提出了重要的网络类和基因网络，以及他们的分析方法。在本研究的最后一部分，作者回顾了旨在分析基因网络的功能组织和网络在医学中的应用的方法。除此之外，作者主张网络作为系统生物学中一般问题的系统方法，因为网络能够承担多种角色，这对于将实验数据与生物学术语的功能解释联系起来非常有益。
The purpose of this study is to survey the use of networks and network-based methods in systems biology. This study starts with an introduction to graph theory and basic measures allowing to quantify structural properties of networks. Then, the authors present important network classes and gene networks as well as methods for their analysis. In the last part of this study, the authors review approaches that aim at analysing the functional organisation of gene networks and the use of networks in medicine. In addition to this, the authors advocate networks as a systematic approach to general problems in systems biology, because networks are capable of assuming multiple roles that are very beneficial connecting experimental data with a functional interpretation in biological terms.