Moderate Physical Activity Mediates the Association between White Matter Lesion Volume and Memory Recall in Breast Cancer Survivors.
Moderate Physical Activity Mediates the Association between White Matter Lesion Volume and Memory Recall in Breast Cancer Survivors.
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DOI：
10.1371/journal.pone.0149552
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Kramer AF
中科院分区：
文献类型：
--
作者：
Cooke GE;Wetter NC;Banducci SE;Mackenzie MJ;Zuniga KE;Awick EA;Roberts SA;Sutton BP;McAuley E;Kramer AF
乳腺癌患者生存率的提高引起了人们对癌症存在的后果以及随后对大脑的治疗相关影响的极大关注。乳腺癌的发病率和治疗效果往往会导致白色物质微观结构的改变和认知功能受损。然而，在许多研究中，身体活动被证明是一种成功的可改变的生活方式因素，可能对乳腺癌幸存者有益。本研究调查了乳腺癌幸存者治疗后与非癌症年龄匹配对照组相比，白色病变体积、适度体力活动和认知之间的联系。结果表明，大脑结构显着预测认知功能，通过调解的身体活动在乳腺癌幸存者。总体而言，该研究提供了初步证据，表明适度的体力活动可能有助于降低与乳腺癌相关的治疗相关风险，包括WM完整性和认知障碍的变化。
Increased survival rates among breast cancer patients have drawn significant attention to consequences of both the presence of cancer, and the subsequent treatment-related impact on the brain. The incidence of breast cancer and the effects of treatment often result in alterations in the microstructure of white matter and impaired cognitive functioning. However, physical activity is proving to be a successful modifiable lifestyle factor in many studies that could prove beneficial to breast cancer survivors. This study investigates the link between white matter lesion volume, moderate physical activity, and cognition in breast cancer survivors following treatment compared to non-cancer age-matched controls. Results revealed that brain structure significantly predicted cognitive function via mediation of physical activity in breast cancer survivors. Overall, the study provided preliminary evidence suggesting moderate physical activity may help reduce the treatment related risks associated with breast cancer, including changes to WM integrity and cognitive impairment.