Efficacy and Tolerability of Armodafinil: Effect on Clinical Condition Late in the Shift and Overall Functioning of Patients With Excessive Sleepiness Associated With Shift Work Disorder
Efficacy and Tolerability of Armodafinil: Effect on Clinical Condition Late in the Shift and Overall Functioning of Patients With Excessive Sleepiness Associated With Shift Work Disorder
复制标题
阿莫达非尼的功效和耐受性：对与轮班工作障碍相关的过度嗜睡患者轮班后期临床状况和整体功能的影响
DOI：
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发表时间：
2011
影响因子：
3.2
通讯作者：
R. Dammerman
中科院分区：
文献类型：
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作者：
M. Erman;D. Seiden;Ronghua Yang;R. Dammerman
Objective: This study examined the effect of armodafinil on late-in-shift clinical condition, wakefulness, and overall functioning of patients with shift work disorder. Methods: Patients with clinically diagnosed shift work disorder received armodafinil or placebo on nights worked for 6 weeks. Patients included in the study experienced late-in-shift sleepiness between 4 AM and 8 AM (Karolinska Sleepiness Scale ≥6) and were functionally impaired (Global Assessment of Functioning <70). Efficacy was determined by improvements in clinical condition (Clinical Global Impression-Change), late-in-the-shift Karolinska Sleepiness Scale score, and overall Global Assessment of Functioning score. Tolerability was assessed. Results: Patients receiving armodafinil showed significant improvements in late-in-shift clinical condition, wakefulness, and global functioning, compared to placebo at final visit. Armodafinil was generally well tolerated. Conclusions: Armodafinil improved clinical condition and wakefulness late in the night shift of patients with shift work disorder. Overall patient functioning was also improved.
