The role of ATP-dependent machines in regulating genome topology.
The role of ATP-dependent machines in regulating genome topology.
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DOI：
10.1016/j.sbi.2016.01.006
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发表时间：
2016-02
影响因子：
6.8
通讯作者：
Berger JM
中科院分区：
文献类型：
--
作者：
Hauk G;Berger JM
所有的细胞都必须根据内部和外部的线索雅阁地复制和表达基因。这些事件的适当时机和响应依赖于高阶基因组组织的主动控制。细胞利用ATP依赖的分子机器来改变DNA的局部和全局拓扑结构，从而促进和抵消转录和复制的持续效应。X射线晶体学和电子显微镜，再加上生物化学和单分子方法正在继续提供丰富的机制信息，如何DNA重塑因子被用来动态地塑造和组织基因组。
All cells must copy and express genes in accord with internal and external cues. The proper timing and response of such events relies on the active control of higher-order genomic organization. Cells use ATP-dependent molecular machines to alter the local and global topology of DNA so as to promote and counteract the persistent effects of transcription and replication. X-ray crystallography and electron microscopy, coupled with biochemical and single molecule methods are continuing to provide a wealth of mechanistic information on how DNA remodeling factors are employed to dynamically shape and organize the genome.