Isolation and mapping of the rabbit DM genes.
Isolation and mapping of the rabbit DM genes.
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兔 DM 基因的分离和定位。
DOI：
10.1007/s002510050496
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发表时间：
1999
期刊：
影响因子：
3.2
通讯作者：
Monaco,JJ
中科院分区：
文献类型：
--
作者：
Hermel,E;Han,M;Hague,B;Kindt,T;Monaco,JJ
主要组织相容性复合体（MHC）编码的II类抗原的适当肽呈递依赖于MHCDMloci的产物。我们鉴定了人hla - dmaa和-DMB的兔同源物（rla - dmaa和-DMB），发现它们与人hla - dmaa和-DMB的同源性分别为76.9%和78.8%。与经典的II类MHC基因一样，RLA-DMgenes与人hla - dmgenes的关系比与小鼠h2 - dm的关系更密切。在dm家族中，DMa链的氨基端具有高度的可变性，DMα和DMβ的细胞质尾部具有高度的长度可变性。兔的dmgene与II类基因在淋巴组织中共表达，其他哺乳动物的dmgene也是如此。TheRLA-DMlocus定位于兔MHC的II类区域，其两侧是dpanddobloci。尽管与硬骨鱼类的II类基因有一些相似之处，dmfamily代表了MHC II类家族的一个独立分支。
Proper peptide presentation by major histocompatibility complex (MHC)-encoded class II antigens is dependent on the products of the MHCDMloci. We identified the rabbit orthologues (RLA-DMAand -DMB) of humanHLA-DMAand -DMBand found that they have 76.9% and 78.8% identity withHLA-DMAand-DMB, respectively. Like classical class II MHC genes,RLA-DMgenes are more closely related to humanHLA-DMgenes than to mouseH2-DM. Among theDMfamily, there is a high degree of variability at the amino terminus of the DMa chains, and length variability in the cytoplasmic tails of both DMα and DMβ. The rabbitDMgenes are coexpressed with class II genes in lymphoid tissues, as are theDMgenes of other mammals. TheRLA-DMlocus maps to the class II region of the rabbit MHC, and is flanked by theDPandDOBloci. Despite having some similarities to class II genes of bony fishes, theDMfamily represents a separate branch of the MHC class II family.