Mitochondria and G-quadruplex evolution: an intertwined relationship.
Mitochondria and G-quadruplex evolution: an intertwined relationship.
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DOI：
10.1016/j.tig.2022.10.006
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发表时间：
2022-11
期刊：
影响因子：
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通讯作者：
V. Sahayasheela;Zutao Yu;Takuya Hidaka;G. Pandian;H. Sugiyama
中科院分区：
文献类型：
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作者：
V. Sahayasheela;Zutao Yu;Takuya Hidaka;G. Pandian;H. Sugiyama
G-四链体（G4 s）是在富含鸟嘌呤（G）的序列中通过Hoogsteen氢键通过堆叠的G四联体形成的非正则结构。一些研究已经证明了G4在包括人类在内的各种生物体的基因组中的存在，并提出G4在各种细胞功能中具有调节作用。然而，关于G4在线粒体中的传播知之甚少。在这篇综述中，我们报告了这样的观察结果：线粒体基因组中潜在的G4形成序列的数量随着不同物种的进化复杂性而增加，这表明G4在高级生物中具有有益的作用。我们还讨论了G4在线粒体（mt）DNA和长链非编码（lnc）RNA中的可能功能及其在各种生物学过程中的作用。
G-quadruplexes (G4s) are non-canonical structures formed in guanine (G)-rich sequences through stacked G tetrads by Hoogsteen hydrogen bonding. Several studies have demonstrated the existence of G4s in the genome of various organisms, including humans, and have proposed that G4s have a regulatory role in various cellular functions. However, little is known regarding the dissemination of G4s in mitochondria. In this review, we report the observation that the number of potential G4-forming sequences in the mitochondrial genome increases with the evolutionary complexity of different species, suggesting that G4s have a beneficial role in higher-order organisms. We also discuss the possible function of G4s in mitochondrial (mt)DNA and long noncoding (lnc)RNA and their role in various biological processes.