Predictors of long-term increase in CD4+ cell counts in human immunodeficiency virus-infected patients receiving a protease inhibitor-containing antiretroviral regimen
Predictors of long-term increase in CD4+ cell counts in human immunodeficiency virus-infected patients receiving a protease inhibitor-containing antiretroviral regimen
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DOI：
10.1086/338929
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发表时间：
2002-02-15
影响因子：
6.4
通讯作者：
Raffi, F
中科院分区：
文献类型：
--
作者：
Le Moing, V;Thiébaut, R;Raffi, F
采用2斜率纵向混合模型，研究了988名在开始含蛋白酶抑制剂的抗逆转录病毒治疗方案时前瞻性入组的患者血浆人类免疫缺陷病毒（HIV） RNA水平与CD4（+）细胞计数进化之间的时间关系。CD4（+）细胞计数平均变化的短期斜率（基线至第4个月）为+21.2细胞/mm(3)/月，长期斜率（第4个月至第24个月）为+5.5细胞/mm(3)/月。与没有病毒反应的患者的结果相比，血浆HIV RNA水平为的患者的长期斜率高2.5个细胞/毫米(3)/月
The temporal relationships between plasma human immunodeficiency virus (HIV) RNA levels and evolution of CD4(+) cell counts was studied, using a 2-slope longitudinal mixed model, in 988 patients prospectively enrolled at the initiation of a protease inhibitor-containing regimen of antiretroviral therapy. The short-term slope (baseline through month 4) for mean change in CD4(+) cell count was +21.2 cells/mm(3)/month, and the long-term slope (month 4 through month 24) was +5.5 cells/mm(3)/month. Compared with results from patients without viral response, the long-term slope was 2.5 cells/mm(3)/month higher in patients who had plasma HIV RNA levels of