Serum VEGF - As a prognostic factor of atherosclerosis
Serum VEGF - As a prognostic factor of atherosclerosis
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DOI：
10.1016/j.atherosclerosis.2006.07.025
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发表时间：
2007-09-01
期刊：
影响因子：
5.3
通讯作者：
Arimura, Kimiyoshi
中科院分区：
文献类型：
--
作者：
Kimura, Kuriko;Hashiguchi, Teruto;Arimura, Kimiyoshi
血管内皮生长因子（VEGF）在动脉粥样硬化的发病机制中已被注意到。为了检验血清VEGF浓度作为动脉粥样硬化指标的有用性，我们分析了443名接受医学检查的成年人的血清VEGF浓度。男性平均血清VEGF浓度（229 ~ 147 pg/ml）显著高于女性（182 ~ 112 pg/ml）。血小板计数与血清VEGF浓度在两种性别中均表现出轻微的相关性（男性R = 0.287，女性R = 0.296），这与血小板是循环外周血中VEGF的主要来源的实验结果相对应。在男性中，血清VEGF浓度与血小板计数、体脂百分比、白细胞计数和HDL-胆固醇浓度相关（负相关）。在对男性血清VEGF浓度进行的多元回归分析中，当除了血小板计数之外还考虑白细胞计数、体脂百分比和HDL-胆固醇浓度时，决定系数（R2）最大化（R2 = 0.173）。男性吸烟者血清VEGF浓度高于非吸烟者。男性吸烟显著影响血清VEGF浓度、白细胞计数和HDL-胆固醇浓度的性别差异。提示血清VEGF浓度与动脉粥样硬化加速因子密切相关，尤其在男性中。(C)2006爱思唯尔爱尔兰有限公司保留所有权利。
Vascular endothelial growth factor (VEGF) has been noted in the pathogenesis of atherosclerosis. To examine the usefulness of the serum concentration of VEGF as an index of atherosclerosis, we analyzed the serum VEGF concentrations in 443 adults who underwent a medical checkup. The mean serum VEGF concentration of men (229 147 pg/ml) was significantly higher than that of women (182 112 pg/ml). The platelet count showed a slight correlation with the serum VEGF concentration in both genders (men R = 0.287, women R = 0.296), corresponding with the results of experiments that platelets are the major source of VEGF in circulating peripheral blood. In men, the serum VEGF concentrations correlated with platelet counts, body fat percentages, leukocyte counts, and HDL-cholesterol concentrations (negative correlation). In the multiple regression analysis performed for men's serum VEGF concentrations, the decision coefficient (R2) was maximized (R2 = 0.173) when the leukocyte count, the body fat percentage, and the HDL-cholesterol concentration were taken into account besides the platelet count. Male smokers' serum VEGF concentrations were higher than non-smokers'. Smoking in men significantly affected the sex difference in the serum VEGF concentration, leukocyte count, and HDL-cholesterol concentration. We concluded that the serum VEGF concentration might be closely related to atherosclerosis accelerating factor, especially in men. (C) 2006 Elsevier Ireland Ltd. All rights reserved.