Alterations in the amplitude and burst distribution of sensorimotor beta oscillations impair reward-dependent motor learning in anxiety
Alterations in the amplitude and burst distribution of sensorimotor beta oscillations impair reward-dependent motor learning in anxiety
复制标题
感觉运动β振荡的振幅和爆发分布的改变会损害焦虑中奖赏依赖性运动学习
DOI：
10.1101/442772
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Sporn S
中科院分区：
文献类型：
--
作者：
Sporn S
焦虑是对未来不可预测的威胁的心理和生理反应，通常会导致次优的运动表现和学习。基于状态焦虑导致仪式化行为（重复，冗余，动作僵硬）的证据，并考虑到运动变异性与运动学习的相关性越来越被认可，我们测试了状态焦虑通过减少行为变异性来损害运动学习的假设。此外，我们预测这种减少是由运动前区和运动皮层的神经变异性变化驱动的。在一项脑电图（EEG）研究中，三组参与者完成了一个基于奖励的运动序列学习范式，运动探索（基线，序列1）和基于奖励的学习（序列2）有不同的阶段。在基线或学习期间操纵焦虑。我们的研究结果表明，焦虑在基线降低运动变异性，破坏随后的奖励为基础的学习。在奖励学习过程中的焦虑并不影响运动变异性，也不损害学习。第二个实验证实，删除基线运动探索导致焦虑减少奖励为基础的学习，从而支持成功的运动学习的相关性不受约束的探索。EEG分析显示，感觉运动β振荡（13- 30 Hz）的变异性的变化介导了焦虑对运动变异性的影响。此外，突发的感觉运动β振荡，生理β的标志，持续时间更长的焦虑的影响下，类似于最近的研究结果的病理生理β运动障碍。我们的研究结果表明，感觉运动β振荡的变异性和爆发持续时间的变化代表了一种神经机制，通过这种机制，焦虑限制了运动变异性，对运动学习产生了不利影响。
Anxiety, a psychological and physiological response to a future unpredictable threat, often results in sub-optimal motor performance and learning. Based on the evidence that state anxiety leads to ritualistic behavior (repetition, redundancy, rigidity of movements), and given the increasingly recognized relevance of movement variability for motor learning, we tested the hypothesis that state anxiety impairs motor learning through a reduction in behavioral variability. Furthermore, we predicted that this reduction is driven by changes in neural variability across premotor and motor cortex. In an electroencephalography (EEG) study, three groups of participants completed a reward-based motor sequence learning paradigm, with separate phases for motor exploration (baseline, sequence1) and reward-based learning (sequence2). Anxiety was manipulated either during baseline or learning. Our results demonstrate that anxiety at baseline reduces motor variability, undermining subsequent reward-based learning. Anxiety during reward-based learning did not affect motor variability, nor did it impair learning. A second experiment confirmed that removal of baseline motor exploration led to anxiety diminishing reward-based learning, thus supporting the relevance of unconstrained exploration for successful motor learning. EEG analysis revealed that changes in the variability of sensorimotor beta oscillations (13-30Hz) mediated the effects of anxiety on motor variability. Moreover, bursts of sensorimotor beta oscillations, a marker of physiological beta, lasted longer under the effect of anxiety, resembling recent findings of pathophysiological beta in movement disorders. Our findings suggest that changes in variability and burst duration in sensorimotor beta oscillations represent a neural mechanism through which anxiety constrains movement variability, with detrimental consequences for motor learning.
登录
查看更多内容
影响因子：
7.7
作者：
Sedley W;Gander PE;Kumar S;Kovach CK;Oya H;Kawasaki H;Howard MA;Griffiths TD
通讯作者：
Griffiths TD
影响因子：
2.7
作者：
Benjamini, Yoav;Krieger, Abba M.;Yekutieli, Daniel
通讯作者：
Yekutieli, Daniel
影响因子：
5.3
作者：
Mandelblat-Cerf, Yael;Paz, Rony;Vaadia, Eilon
通讯作者：
Vaadia, Eilon
影响因子：
0.9
作者：
Basso, Dario;Chiarandini, Marco;Salmaso, Luigi
通讯作者：
Salmaso, Luigi
影响因子：
7.7
作者：
Kornysheva K;Diedrichsen J
通讯作者：
Diedrichsen J