The Role of Glutathione in Transport Activity in Kidney
The Role of Glutathione in Transport Activity in Kidney
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谷胱甘肽在肾脏转运活动中的作用
DOI：
10.1007/978-3-642-67132-6_11
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发表时间：
1978
期刊：
影响因子：
4.5
通讯作者：
D. Pashley
中科院分区：
文献类型：
--
作者：
F. Leibach;D. Pillion;J. Mendicino;D. Pashley
二酰胺氧化肾皮质GSH，并导致肾皮质切片中氨基酸和糖摄取以及新生血管生成的抑制。然而，它不抑制对氨基马尿酸的摄取。二酰胺的作用可以通过添加外源性GSH来逆转，而其他硫醇的效果较差。二酰胺不影响肾脏γ-谷氨酰转肽酶、碱性磷酸酶或Mg 2 +-ATP酶，但抑制蛋白激酶活性（可溶性和颗粒性）、微粒体Na+-K+-依赖性ATP酶和葡萄糖-6-磷酸酶。这些酶的抑制作用是部分可逆的外源性硫醇后加入。结果提示，GSH与肾脏的转运过程密切相关。
Diamide oxidizes renal cortical GSH and causes inhibition of amino acid and sugar uptake and gluconeogenesis in the renal cortical slice. However, it does not inhibit the uptake of p-aminohippurate. The effects of diamide can be reversed by the addition of exogenous GSH, while other thiols are less effective. Diamide does not affect renal γ-Glutamyl transpeptidase, alkaline phosphatase, or Mg2+-ATPase, but does inhibit protein kinase activity, both soluble and particulate, microsomal Na+-K+-dependent ATPase and glucose-6-phosphatase. The inhibition of these enzymes is partially reversible upon addition of exogenous thiols. The results suggest that GSH is intimately associated with transport processes in kidney.