Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes
Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes
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DOI：
10.1073/pnas.97.7.3382
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发表时间：
2000-03-28
影响因子：
11.1
通讯作者：
Phillips, RE
中科院分区：
文献类型：
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作者：
Oxenius, A;Price, DA;Phillips, RE
高效抗逆转录病毒疗法(HAART)一直被提倡用于治疗原发HIV-1感染，但对其免疫学效应没有明确的了解。在这里，我们证明了在初次感染期间早期使用HAART在物理和功能上保留了HIV特异性CD8(+)T细胞，同时维持了HIV特异性T细胞帮助，我们还表明，即使在血清转换时短暂使用HAART也可以保护HIV特异性免疫。相反，HAART的延迟启动与HIV特异性CD8(+)T细胞的进行性丧失和缺乏HIV特异性T细胞帮助有关。这些结果表明，在初次感染HIV-1的过程中，HIV特异性T HELP受到了破坏。早期药物治疗保留了这种免疫力，也保留了HIV特异性CD8(+)T细胞。这些结果对了解HIV-1感染的早期发病机制具有重要意义，并建议应尽早积极治疗急性HIV感染。
Highly active antiretroviral therapy (HAART) has been advocated for the management of primary HIV-1 infection without clear understanding of its immunological effects. Here, we demonstrate that early use of HAART during primary infection preserves HIV-specific CD8(+) T cells physically and functionally while HIV-specific T cell help is sustained, We also show that even transient administration of HAART at seroconversion can preserve HIV-specific immunity. In contrast, delayed initiation of HAART is associated with a progressive loss of HIV-specific CD8(+) T cells and absent HIV-specific T cell help. These results imply that HIV-specific T help is damaged during primary HIV-1 infection. Early drug treatment, which preserves this immunity, also preserves HIV-specific CD8(+) T cells. These results have implications for understanding the early pathogenesis of HIV-1 infection and suggest that acute HIV infection should be treated aggressively and as early as possible.