Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects.
Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects.
复制标题
可生物降解的镁铜合金，具有增强成骨、血管生成和持久抗菌作用
DOI：
10.1038/srep27374
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发表时间：
2016-06-07
影响因子：
4.6
通讯作者：
Chu PK
中科院分区：
文献类型：
--
作者：
Liu C;Fu X;Pan H;Wan P;Wang L;Tan L;Wang K;Zhao Y;Yang K;Chu PK
一系列可生物降解的Mg-Cu合金被设计用于诱导成骨，刺激血管生成，同时提供持久的抗菌性能。含有Mg 2Cu金属间化合物相的Mg-Cu合金在生理环境中由于电偶腐蚀而表现出加速的降解，并且碱性环境与Cu释放相结合赋予Mg-Cu合金延长的抗菌效果。除了对HUVEC和MC 3 T3-E1细胞没有细胞毒性之外，与纯Mg相比，Mg-Cu合金，特别是Mg-0.03Cu，增强了MC 3 T3-E1细胞的细胞活力、碱性磷酸酶活性、基质矿化、胶原分泌、成骨相关基因和蛋白表达、HUVEC的细胞增殖、迁移、内皮小管形成、血管生成相关基因和蛋白表达。镁铜合金具有良好的成骨和血管生成能力，可生物降解的镁铜合金具有成骨、血管生成和长期抗菌的功能，在骨科应用中具有广阔的前景。
A series of biodegradable Mg-Cu alloys is designed to induce osteogenesis, stimulate angiogenesis, and provide long-lasting antibacterial performance at the same time. The Mg-Cu alloys with precipitated Mg2Cu intermetallic phases exhibit accelerated degradation in the physiological environment due to galvanic corrosion and the alkaline environment combined with Cu release endows the Mg-Cu alloys with prolonged antibacterial effects. In addition to no cytotoxicity towards HUVECs and MC3T3-E1 cells, the Mg-Cu alloys, particularly Mg-0.03Cu, enhance the cell viability, alkaline phosphatase activity, matrix mineralization, collagen secretion, osteogenesis-related gene and protein expressions of MC3T3-E1 cells, cell proliferation, migration, endothelial tubule forming, angiogenesis-related gene, and protein expressions of HUVECs compared to pure Mg. The favorable osteogenesis and angiogenesis are believed to arise from the release of bioactive Mg and Cu ions into the biological environment and the biodegradable Mg-Cu alloys with osteogenesis, angiogenesis, and long-term antibacterial ability are very promising in orthopedic applications.