COMPARISON OF NORMAL AND ASTHMATIC CIRCADIAN-RHYTHMS IN PEAK EXPIRATORY FLOW-RATE
COMPARISON OF NORMAL AND ASTHMATIC CIRCADIAN-RHYTHMS IN PEAK EXPIRATORY FLOW-RATE
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DOI：
10.1136/thx.35.10.732
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发表时间：
1980-01-01
期刊：
影响因子：
10
通讯作者：
CLARK, TJH
中科院分区：
文献类型：
--
作者：
HETZEL, MR;CLARK, TJH
应用计算机技术（余弦分析）评价正常人和哮喘患者气道口径的昼夜节律。正常受试者[221]在家中记录峰值呼气流速（PEFR）4 × 10 - 4。一天七天。其中145人（65.6%）的节律检测具有统计学显著性，其平均振幅为个体平均PEFR的8.3%（±）。SD 5.2%）。振幅与年龄、性别、哮喘家族史、吸烟习惯无关。其中，15个也被研究了3次。在实验室中使用流量-体积回路，连续5天。11例在家中表现出显著的PEFR节律。没有一个流量-容积环的单一测量显示其中许多人的周期性，但现在在其他4名正常受试者的环的某些组成部分中也检测到节律。哮喘患者[56]采用类似的PEFR测量方案进行研究，并与145名节律正常的受试者进行比较。正常和哮喘节律的平均相位分别在1557和1526处与峰值相位（节律周期的峰值）没有显著差异。平均哮喘振幅显著更大，为50.9%。夜间哮喘可能代表气道口径正常昼夜节律的夸大。PEFR节律的振幅是支气管不稳定性的指标，在监测哮喘患者中有价值。振幅> 20%应该是一个有用的哮喘筛查试验。
A computer technique (cosinor analysis) was used to evaluate circadian rhythms in airway caliber in normals and asthmatics. Normal subjcts [221] recorded peak expiratory flow rate (PEFR) at home 4 .times./day for 7 days. Rhythm detection was statistically significant in 145 of them (65.6%) who showed a mean amplitude of 8.3% of individual mean PEFR (.+-. SD 5.2%). Amplitude was independent of age, sex atopy, family history of asthma and smoking habit. Of them, 15 were also studied 3 .times./day for 5 days in the laboratory with flow-volume loops. Eleven showed significant PEFR rhythms at home. No single measurement from the flow-volume loop showed periodicity in as many of them but rhythms were now also detected in the other 4 normal subjects in some components of the loop. Asthma patients [56] were studied with a similar protocol of PEFR measurement and compared to the 145 rhythmic normal subjects. Mean phases of the normal and asthmatic rhythms were not significantly different with acrophases (peak of rhythm cycle) at 1557 and 1526, respectively. The mean asthmatic amplitude was significantly greater at 50.9%. Nocturnal asthma probably represents an exaggeration of a normal circadian rhythm in airway caliber. The amplitude of the PEFR rhythm is an index of bronchial lability and is valuable in monitoring asthma patients. An amplitude of > 20% should be a useful screening test for asthma.