A Multifunctional Integrated Metal-Free MRI Agent for Early Diagnosis of Oxidative Stress in a Mouse Model of Diabetic Cardiomyopathy.
A Multifunctional Integrated Metal-Free MRI Agent for Early Diagnosis of Oxidative Stress in a Mouse Model of Diabetic Cardiomyopathy.
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DOI：
10.1002/advs.202206171
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发表时间：
2023-03
期刊：
影响因子：
15.1
通讯作者：
Wang, Xu
中科院分区：
文献类型：
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作者：
Nie, Zhuang;Zhang, Kun;Chen, Xinyu;Wang, Jingxin;Gao, Huile;Zheng, Bingwen;Wu, Qihong;Guo, Yingkun;Liu, Xiangyang;Wang, Xu
关键词：
活性氧（Reactive oxygen species，ROS）与糖尿病性心肌病（diabetic cardiomyopathy，DCM）的发生发展密切相关，可作为DCM的早期生物标志物之一。磁共振成像（MRI）正在成为检测心脏异常的有力工具，但灵敏和直接的ROS反应MRI探头仍有待开发。这限制了扩张型心肌病的早期诊断，并阻止了及时的临床干预，导致严重和不可逆的病理生理异常。本文中，通过用多羟基和2，2，6，6-四甲基哌啶-1-氧基多官能化氟化碳纳米片（FCN）开发了新型ROS响应对比增强MRI纳米探针（RCMN）。RCMNs捕获活性氧并暂时聚集在心脏内，触发MRI信号变化，实现活性氧的体内检测。与临床MRI试剂相比，在RCMNs的辅助下，疾病小鼠的心脏异常被提前8周检测到，这大大提前了DCM的诊断窗口。据我们所知，这是第一个用于DCM小鼠模型早期诊断的ROS响应无金属T2加权MRI探头。此外，RCMNs还能及时抑制过量产生的ROS，减轻氧化应激。这是一种新型的无金属ROS敏感MRI探针（RCMNs），通过使用FCN作为功能载体，用于小鼠模型中DCM的早期诊断。与常规MRI相比，RCMNs可提前8周发现心脏异常。此外，RCMNs还能及时抑制过量产生的ROS，减轻氧化应激。
Reactive oxygen species (ROS) are closely associated with the progression of diabetic cardiomyopathy (DCM) and can be regarded as one of its early biomarkers. Magnetic resonance imaging (MRI) is emerging as a powerful tool for the detection of cardiac abnormalities, but the sensitive and direct ROS‐response MRI probe remains to be developed. This restricts the early diagnosis of DCM and prevents timely clinical interventions, resulting in serious and irreversible pathophysiological abnormalities. Herein, a novel ROS‐response contrast‐enhanced MRI nanoprobe (RCMN) is developed by multi‐functionalizing fluorinated carbon nanosheets (FCNs) with multi‐hydroxyl and 2,2,6,6‐tetramethylpiperidin‐1‐oxyl groups. RCMNs capture ROS and then gather in the heart provisionally, which triggers MRI signal changes to realize the in vivo detection of ROS. In contrast to the clinical MRI agents, the cardiac abnormalities of disease mice is detected 8 weeks in advance with the assistance of RCMNs, which greatly advances the diagnostic window of DCM. To the best of the knowledge, this is the first ROS‐response metal‐free T2‐weighted MRI probe for the early diagnosis of DCM mice model. Furthermore, RCMNs can timely scavenge excessively produced ROS to alleviate oxidative stress. This is a novel, metal‐free ROS‐sensitive MRI probe (RCMNs) for the early diagnosis of DCM in mice models by using the FCNs as functional carriers. Compared with conventional MRI agents, the cardiac abnormalities are detected 8 weeks in advance with assistance of RCMNs. Furthermore, RCMNs can timely scavenge excessively produced ROS to alleviate oxidative stress.
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DOI：
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发表时间：
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期刊：
Antioxidants (Basel, Switzerland)
影响因子：
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作者：
通讯作者：
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