Dynorphins regulate the strength of social memory
Dynorphins regulate the strength of social memory
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DOI：
10.1016/j.neuropharm.2013.10.023
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发表时间：
2014-02-01
影响因子：
4.7
通讯作者：
Zimmer, A.
中科院分区：
文献类型：
--
作者：
Bilkei-Gorzo, A.;Mauer, D.;Zimmer, A.
引起警觉的事件，如遇到不熟悉的同类，会产生强烈而生动的记忆，海马体和杏仁核在其中起着至关重要的作用。然而，人们对哪些神经递质系统调节具有强烈情感成分的社会记忆的强度却知之甚少。先前的研究表明，强啡肽信号与恐惧记忆的形成和消失有关，因此我们询问它是否也会影响社交记忆。具有前强啡肽基因Pdyn（Pdyn（-/-））的遗传缺失的小鼠显示出上级伴侣识别能力，而它们在物体识别测试中的表现与野生型小鼠相同。药理学阻断κ阿片受体（KOR）导致野生型动物的社会记忆增强，而KOR的激活降低了Pdyn（-/-）小鼠的识别能力。同伴再认测试情境诱导了中央杏仁核和基底外侧杏仁核以及海马中强啡肽A水平的较高升高，并且海马中强啡肽B水平也高于物体再认测试情境。我们的结果表明，强啡肽系统的活动增加，在情绪激动的情况下，它减少了社会记忆的形成。因此，强啡肽信号通过减少经验中的情感成分而参与社会记忆的形成。(C)2013爱思唯尔有限公司保留所有权利。
Emotionally arousing events like encounter with an unfamiliar con-species produce strong and vivid memories, whereby the hippocampus and amygdala play a crucial role. It is less understood, however, which neurotransmitter systems regulate the strength of social memories, which have a strong emotional component. It was shown previously that dynorphin signalling is involved in the formation and extinction of fear memories, therefore we asked if it influences social memories as well. Mice with a genetic deletion of the prodynorphin gene Pdyn (Pdyn(-/-)) showed a superior partner recognition ability, whereas their performance in the object recognition test was identical as in wild-type mice. Pharmacological blockade of kappa opioid receptors (KORs) led to an enhanced social memory in wild-type animals, whereas activation of KORs reduced the recognition ability of Pdyn(-/-) mice. Partner recognition test situation induced higher elevation in dynorphin A levels in the central and basolateral amygdala as well as in the hippocampus, and also higher dynorphin B levels in the hippocampus than the object recognition test situation. Our result suggests that dynorphin system activity is increased in emotionally arousing situation and it decreases the formation of social memories. Thus, dynorphin signalling is involved in the formation of social memories by diminishing the emotional component of the experience. (C) 2013 Elsevier Ltd. All rights reserved.