GABA Shapes the Dynamics of Bistable Perception
GABA Shapes the Dynamics of Bistable Perception
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DOI：
10.1016/j.cub.2013.03.067
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发表时间：
2013-05-06
期刊：
影响因子：
9.2
通讯作者：
Lamme, Victor A. F.
中科院分区：
文献类型：
--
作者：
van Loon, Anouk M.;Knapen, Tomas;Lamme, Victor A. F.
有时，感知会自发地在对恒定感觉输入的两种不同解释之间波动。这些非知觉现象为了解创造有意识知觉内容的神经机制提供了一个独特的窗口[1]。视皮层刺激选择性神经元之间的相互抑制在这些自发的知觉波动中起着关键作用[2，3]。然而，神经抑制和神经感知之间的直接联系尚未在实验上建立。在这里，我们链接感知动力学在三个不同的视觉错觉（双眼竞争，运动引起的失明，结构从运动）的测量γ-氨基丁酸（GABA）浓度在人类视觉皮层（如测量磁共振光谱）和药理刺激的GABA（A）受体的劳拉西泮。作为预测的模型的神经相互作用的基础双稳态，无论是在视觉皮层和劳拉西泮管理较高的GABA浓度诱导较慢的感知动力学，反映在感知开关的数量减少和延长的adhesept持续时间。因此，我们表明，GABA，主要的抑制性神经递质，形状的动态感知。这些结果铺平了道路，为未来的研究竞争性的神经相互作用的视觉皮层层次结构，引起有意识的知觉。
Sometimes, perception fluctuates spontaneously between two distinct interpretations of a constant sensory input. These bistable perceptual phenomena provide a unique window into the neural mechanisms that create the contents of conscious perception [1]. Models of bistable perception posit that mutual inhibition between stimulus-selective neural populations in visual cortex plays a key role in these spontaneous perceptual fluctuations [2, 3]. However, a direct link between neural inhibition and bistable perception has not yet been established experimentally. Here, we link perceptual dynamics in three distinct bistable visual illusions (binocular rivalry, motion-induced blindness, and structure from motion) to measurements of gamma-aminobutyric acid (GABA) concentrations in human visual cortex (as measured with magnetic resonance spectroscopy) and to pharmacological stimulation of the GABA(A) receptor by means of lorazepam. As predicted by a model of neural interactions underlying bistability, both higher GABA concentrations in visual cortex and lorazepam administration induced slower perceptual dynamics, as reflected in a reduced number of perceptual switches and a lengthening of percept durations. Thus, we show that GABA, the main inhibitory neurotransmitter, shapes the dynamics of bistable perception. These results pave the way for future studies into the competitive neural interactions across the visual cortical hierarchy that elicit conscious perception.