Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride
Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride
复制标题
四氯化碳诱导纤维化肝脏中时钟基因的昼夜节律改变
DOI：
10.1016/j.febslet.2010.03.019
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发表时间：
2010-04-16
期刊：
影响因子：
3.5
通讯作者：
Zhang, Jianfa
中科院分区：
文献类型：
--
作者：
Chen, Peng;Kakan, Xiamusiya;Zhang, Jianfa
昼夜节律的破坏，无论是在老鼠突变或轮班工作的人，与多器官疾病的发展风险增加。反过来，器官疾病可能会影响生物钟基因和外周昼夜节律系统的功能。在这里，我们表明，四氯化碳诱导的小鼠肝纤维化导致肝脏时钟基因的昼夜节律的改变。特别是，我们发现在纤维化肝脏中的Cry 2日节律受损，与对照肝脏相比，白天的水平显著降低。与此相关，两个重要的时钟调节基因过氧化物酶体增殖物激活受体α和细胞色素P450氧化还原酶的表达失去了昼夜节律，在光暗（12/12小时）周期中纤维化肝脏的水平显着下降。(C)2010年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
Disruption in circadian rhythms either by mutation in mice or by shiftwork in people, is associated with an increased risk for the development of multiple organ diseases. In turn, organ disease may influence the function of clock genes and peripheral circadian systems. Here we showed that hepatic fibrosis induced by carbon tetrachloride in mice leads to alterations in the circadian rhythms of hepatic clock genes. Especially, we found an impaired daily Cry2 rhythm in the fibrotic livers, with markedly decreased levels during the day time while compared with control livers. Associatively, the expressions of two important clock-regulated genes peroxisome proliferator-activated receptor alpha and cytochrome P450 oxidoreductase lost circadian rhythm with significantly decreased levels during the light-dark (12/12 h) cycle in fibrotic livers. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.