SINGLE PHOTON-EMISSION COMPUTED-TOMOGRAPHY IN ALZHEIMERS-DISEASE - ABNORMAL IOFETAMINE-I 123 UPTAKE REFLECTS DEMENTIA SEVERITY
SINGLE PHOTON-EMISSION COMPUTED-TOMOGRAPHY IN ALZHEIMERS-DISEASE - ABNORMAL IOFETAMINE-I 123 UPTAKE REFLECTS DEMENTIA SEVERITY
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DOI：
10.1001/archneur.1988.00520280038013
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发表时间：
1988-04-01
影响因子：
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通讯作者：
GROWDON, JH
中科院分区：
文献类型：
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作者：
JOHNSON, KA;HOLMAN, BL;GROWDON, JH
为了确定在轻度或中度以及重度阿尔茨海默病 (AD) 病例中是否可以检测到通过盐酸碘非他明 I 123 和单光子发射计算机断层扫描估计的局部脑功能活动异常，我们对 37 名疑似 AD 患者（9 名轻度痴呆患者、18 名中度痴呆患者和 10 名重度痴呆患者）和 9 名年龄匹配的对照患者进行了碘非他明 I 123 单光子发射计算机断层扫描科目。测量左右额叶、颞叶、顶叶和枕叶皮质的碘非他明 I 123 摄取量。与对照受试者相比，AD 患者顶叶区域的平均（右和左）碘非他明 I 123 活性最低，其他三个区域显着降低。仅在顶叶区域，碘非他明 I 123 的相对活性较低，与患者功能受损和认知缺陷相关。
To determine whether abnormalities in regional cerebral functional activity estimated by iofetamine hydrochloride I 123 and single photon emission computed tomography can be detected in mild or moderate as well as severe cases of Alzheimer''s disease (AD), we performed iofetamine I 123-single photon emission computed tomography in 37 patients with probable AD (nine patients with mild, 18 patients with moderate, and ten patients with severe dementia) and nine age-matched control subjects. Iofetamine I 123 uptake was measured in right and left frontal, temporal, parietal, and occipital cortices. Mean (right and left) iofetamine I 123 activity was lowest in the parietal region of patients with AD and was significantly reduced in the other three regions compared with control subjects. Only in the parietal region was lower relative iofetamine I 123 activity associated with an impaired level of patient function and with cognitive deficit.