Glutamate signaling from a single sensory neuron mediates experience-dependent bidirectional behavior in Caenorhabditis elegans
Glutamate signaling from a single sensory neuron mediates experience-dependent bidirectional behavior in Caenorhabditis elegans
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DOI：
10.1016/j.celrep.2021.109177
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发表时间：
2021-05-25
期刊：
影响因子：
8.8
通讯作者：
Iino, Yuichi
中科院分区：
文献类型：
--
作者：
Sato, Hirofumi;Kunitomo, Hirofumi;Iino, Yuichi
动物的定向和导航行为受到过去经验的调节。然而，很少有人知道的机制，感觉输入被翻译成多方向定向行为的经验依赖的方式。在这里，我们报告的双向盐浓度趋化性的秀丽隐杆线虫的神经机制。盐敏感神经元ASE right（ASER）总是被盐浓度的降低所激活，而重定向行为的方向性则取决于先前的盐经验。AIB是ASER突触后的中间神经元，AIB下游的神经元表现出经验依赖性的双向反应，这与重定向行为相关。这些双向行为和神经反应由ASER释放的谷氨酸介导。谷氨酸通过兴奋性谷氨酸受体GLR-1和抑制性谷氨酸受体AVR-14起作用，两者都在AIB中起作用。这些发现表明，经验依赖性重定向行为是通过改变从感觉神经元到中间神经元的兴奋性和抑制性突触后信号的大小而产生的。
Orientation and navigation behaviors of animals are modulated by past experiences. However, little is known about the mechanisms by which sensory inputs are translated into multi-directional orientation behaviors in an experience-dependent manner. Here, we report a neural mechanism for bidirectional salt-concentration chemotaxis of Caenorhabditis elegans. The salt-sensing neuron ASE right (ASER) is always activated by a decrease of salt concentration, while the directionality of reorientation behaviors is inverted depending on previous salt experiences. AIB, the interneuron postsynaptic to ASER, and neurons farther downstream of AIB show experience-dependent bidirectional responses, which are correlated with reorientation behaviors. These bidirectional behavioral and neural responses are mediated by glutamate released from ASER. Glutamate acts through the excitatory glutamate receptor GLR-1 and inhibitory glutamate receptor AVR-14, both acting in AIB. These findings suggest that experience-dependent reorientation behaviors are generated by altering the magnitude of excitatory and inhibitory postsynaptic signals from a sensory neuron to intemeurons.