Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones.
Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones.
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DOI：
10.1053/j.ajkd.2015.09.005
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发表时间：
2016-03
期刊：
影响因子：
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通讯作者：
Taylor EN
中科院分区：
文献类型：
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作者：
Ferraro PM;Curhan GC;Gambaro G;Taylor EN
之前关于维生素 C 和肾结石的研究主要在男性中进行，要么报告了补充剂和膳食维生素 C 的不同结果，要么没有检查膳食维生素 C。前瞻性队列分析。护士健康研究 (NHS) I 和 II 中有 156,735 名女性参与，健康专业人员随访研究 (HPFS) 中有 40,536 名男性参与。膳食和补充维生素 C 的总摄入量，根据年龄、BMI、噻嗪类药物的使用和饮食因素进行调整。肾结石事件 在中位随访 11.3-11.7 年期间，发现了 6,245 例肾结石事件。经过多变量调整后，维生素 C 摄入总量（<90 [参考]、90–249、250–499、500–999 和 ≥1,000 mg/d）与女性肾结石风险没有显着相关，但在男性中却与肾结石风险显着相关（HR 为 1.00 [参考]、1.19 [95% CI，0.99–1.46]、1.15 [95% CI，0.93–1.42]、1.29 [95% CI，1.04–1.60] 和 1.43 [95% CI，1.15–1.79]；趋势 p = 0.005）。 500-999 毫克/天类别的维生素 C 总摄入量中位数约为 700 毫克/天。补充维生素 C 摄入量（无用[参考]、<500、500–999 和 ≥1,000 mg/d）与女性肾结石风险没有显着相关，但在男性中却与肾结石风险显着相关（≥1,000 mg/d 时 HR，1.19 [95% CI，1.01–1.40]；趋势 p = 0.001）。膳食维生素 C 摄入量与男性或女性结石无关，尽管很少有参与者的膳食摄入量 >700 毫克/天。营养摄入量来自食物频率调查问卷，缺乏所有病例的结石成分数据。维生素 C 的总量和补充摄入量与男性患肾结石的较高风险显着相关，但与女性无关。
Previous studies of vitamin C and kidney stones were conducted mostly in men and either reported disparate results for supplemental and dietary vitamin C or did not examine dietary vitamin C. Prospective cohort analysis. 156,735 women in the Nurses’ Health Study (NHS) I and II and 40,536 men in the Health Professionals Follow-up Study (HPFS). Total, dietary and supplemental vitamin C intake, adjusted for age, BMI, thiazide use, and dietary factors. Incident kidney stones During median follow-up of 11.3–11.7 years, 6,245 incident kidney stones were identified. After multivariable adjustment, total vitamin C intake (<90 [reference], 90–249, 250–499, 500–999 and ≥1,000 mg/d) was not significantly associated with the risk of kidney stones among women, but was among men (HRs of 1.00 [reference], 1.19 [95% CI, 0.99–1.46], 1.15 [95% CI, 0.93–1.42], 1.29 [95% CI, 1.04–1.60] and 1.43 [95% CI, 1.15–1.79], respectively; p for trend = 0.005). Median total vitamin C intake for the 500–999 mg/d category was about 700 mg/d. Supplemental vitamin C intake (no use [reference], <500, 500–999, and ≥1,000 mg/d) was not significantly associated with the risk of kidney stones among women, but was among men (HR, 1.19 [95% CI, 1.01–1.40] for ≥1,000 mg/d; p for trend = 0.001). Dietary vitamin C intake was not associated with stones among men or women, although few participants had dietary intakes >700 mg/d. Nutrient intakes derived from food-frequency questionnaires, lack of data on stone composition for all the cases. Total and supplemental intake of vitamin C was significantly associated with a higher risk of incident kidney stones in men, but not among women.