A functional MRI study of visual oddball: evidence for frontoparietal dysfunction in subjects at risk for alcoholism.
A functional MRI study of visual oddball: evidence for frontoparietal dysfunction in subjects at risk for alcoholism.
复制标题
视觉怪异的功能性核磁共振研究：有酗酒风险的受试者额顶叶功能障碍的证据。
DOI：
10.1016/j.neuroimage.2003.09.018
复制
发表时间：
2004
期刊：
影响因子：
5.7
通讯作者：
Begleiter,Henri
中科院分区：
文献类型：
--
作者：
Rangaswamy,Madhavi;Porjesz,Bernice;Ardekani,BabakA;Choi,StevenJ;Tanabe,JodyL;Lim,KelvinO;Begleiter,Henri
注意散布在重复频繁刺激中的罕见刺激在目标刺激开始后300至600 ms产生正头皮电位;该电位被称为P300波。虽然有明确的证据表明，低视觉P300在高风险（HR）的受试者发展为酒精中毒，功能神经解剖学的相关性尚未研究。功能和高分辨率的解剖磁共振图像的视觉古怪的任务，从6个控制（低风险-LR）的主题与高P300和8个HR主题与低P300的性能期间收集。所有的HR受试者都是男性酗酒者的后代。使用基于随机化的统计方法分析数据，该方法考虑了多重比较，不需要对数据的噪声结构进行假设，也不需要空间或时间平滑。目标计数显示所有受试者都完成了任务。功能磁共振成像（fMRI）数据的分析显示，HR组与LR组相比，激活显著降低的两个区域：双侧顶下小叶（BA 40）和双侧额下回（BA 44）。HR组顶下小叶的激活显著低于LR组，HR组额下回未激活，而LR组仅激活。这一发现表明，功能失调的额顶叶电路可能导致低的P300反应在HR科目。这可能意味着工作记忆系统的排练部分存在缺陷。
Attending to rare stimuli interspersed among repetitive frequent stimuli produces a positive scalp potential at 300 to 600 ms after the target stimulus onset; this potential is known as the P300 wave. Although there is clear evidence of low visual P300 in subjects at high risk (HR) for developing alcoholism, the functional neuroanatomical correlates have not been studied. Functional and high-resolution anatomical magnetic resonance images were collected during the performance of a visual oddball task, from six control (low risk—LR) subjects with high P300s and eight HR subjects with low P300s. All the HR subjects were offspring of male alcoholics. The data were analyzed using a randomization-based statistical method that accounts for multiple comparisons, requires no assumptions about the noise structure of the data, and does not require spatial or temporal smoothing. Target counts showed that all subjects performed the task comparably. Analysis of the functional magnetic resonance imaging (fMRI) data revealed two areas with significantly lower activation in the HR group when compared to the LR group: the bilateral inferior parietal lobule (BA 40), and the bilateral inferior frontal gyrus (BA 44). Inferior parietal lobule showed significantly lower activation in the HR group in contrast to the LR group, and inferior frontal gyrus was not activated in the HR group but was only activated in the LR group. This finding indicates that a dysfunctional frontoparietal circuit may underlie the low P300 responses seen in HR subjects. This perhaps implies a deficiency in the rehearsal component of the working memory system.