Health-related quality of life in relation to metabolic control and late complications in patients with insulin dependent diabetes mellitus
Health-related quality of life in relation to metabolic control and late complications in patients with insulin dependent diabetes mellitus
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DOI：
10.1007/bf00435977
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发表时间：
1996-02-01
影响因子：
3.5
通讯作者：
Wibell, L
中科院分区：
文献类型：
--
作者：
Wikblad, K;Leksell, J;Wibell, L
为了探讨影响长期胰岛素依赖型糖尿病患者健康相关生活质量(HRQOL)的重要因素，前瞻性地对一组患者进行了10年的跟踪调查。评估代谢控制程度和晚期并发症的存在，并使用61项问卷(SWEDQUAL)测量HRQOL，其中参考值已在人群样本中获得。结果表明，糖尿病患者(n=108)的生活质量与普通人群一样好。当根据代谢控制将患者分为四组时，控制不良(HbA1c大于或等于9%)的患者对他们的身体和情绪功能的评分明显低于HbA1c较低的患者。近15%的患者报告在最近6个月内发生了1-5次低血糖发作。尽管HbA1c较低，但他们认为他们的总体健康状况比没有严重低血糖的患者更差。在108名患者中，39%的患者似乎没有糖尿病的晚期并发症。这些患者对他们的总体健康状况的评价比那些已经出现晚期并发症的患者要好。我们的结论是，令人满意的代谢控制和最少的低血糖发作不仅是为了预防晚期并发症，而且因为糟糕的代谢控制似乎是糖尿病患者生活质量较差的原因之一。
To investigate important factors with respect to health-related quality of life (HRQOL) in patients with longstanding insulin dependent diabetes mellitus, a patient cohort was followed prospectively for 10 years. The degree of metabolic control and the presence of late complications was assessed and HRQOL was measured with a 61-item questionnaire (SWEDQUAL) in which reference values have been obtained in a population sample. The results indicate that diabetic patients (n=108) experienced a quality of life as good as a general population. When patients were divided into four groups based on metabolic control, those with poor control (HbA1c greater than or equal to 9%) rated their physical and emotional functioning significantly lower than those with lower HbA1c values. Nearly 15% of the patients reported 1-5 hypoglycaemic episodes during the latest 6 months. Despite a lower HbA1c they rated their general health as being poorer than patients without severe hypoglycaemia. Of the 108 patients 39% appeared to be free from late complications of diabetes. These patients rated their general health as better than patients who already had developed late complications. We conclude that a satisfactory metabolic control with a minimum of hypoglycaemic episodes is desirable not only to prevent late complications but also because poor metabolic control seems to be one reason why diabetic patients experience a poorer quality of life.