Mitochondria in the regulation of innate and adaptive immunity.
Mitochondria in the regulation of innate and adaptive immunity.
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DOI：
10.1016/j.immuni.2015.02.002
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发表时间：
2015-03-17
期刊：
影响因子：
32.4
通讯作者：
Chandel, Navdeep S.
中科院分区：
文献类型：
--
作者：
Weinberg, Samuel E.;Sena, Laura A.;Chandel, Navdeep S.
线粒体作为生物合成和生物能量的细胞器，其作用受到广泛的赞赏。在过去的二十年中，线粒体已经成为信号细胞器，有助于细胞增殖，死亡和分化的关键决定。线粒体不仅维持免疫细胞表型，而且是建立免疫细胞表型及其功能所必需的。线粒体可以从主要产生ATP的分解代谢细胞器迅速转变为产生ATP和用于大分子合成的构件的合成代谢细胞器。这使它们能够满足不同免疫细胞的适当代谢需求。线粒体具有多种机制，使其能够激活胞质溶胶中的信号传导途径，包括改变AMP/ATP比率、ROS和TCA循环代谢物的释放以及免疫调节蛋白在线粒体外膜上的定位。在这篇综述中，我们讨论了线粒体依赖信号控制先天性和适应性免疫反应的证据和机制。
Mitochondria are well appreciated for their role as biosynthetic and bioenergetic organelles. In the past two decades, mitochondria have emerged as signaling organelles that contribute critical decisions about cell proliferation, death and differentiation. Mitochondria not only sustain immune cell phenotypes but also are necessary for establishing immune cell phenotype and their function. Mitochondria can rapidly switch from primarily being catabolic organelles generating ATP to anabolic organelles that generate both ATP and building blocks for macromolecule synthesis. This enables them to fulfill appropriate metabolic demands of different immune cells. Mitochondria have multiple mechanisms that allow them to activate signaling pathways in the cytosol including altering in AMP/ATP ratio, the release of ROS and TCA cycle metabolites, as well as the localization of immune regulatory proteins on the outer mitochondrial membrane. In this Review, we discuss the evidence and mechanisms that mitochondrial dependent signaling controls innate and adaptive immune responses.
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影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
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Pearce EL
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64.5
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影响因子：
4.4
作者：
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通讯作者：
Sitia, Roberto
影响因子：
20.3
作者：
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通讯作者：
Pearce, Edward J.