How best to consider the structure and function of the pedunculopontine tegmental nucleus: Evidence from animal studies
How best to consider the structure and function of the pedunculopontine tegmental nucleus: Evidence from animal studies
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DOI：
10.1016/j.jns.2006.05.036
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发表时间：
2006-10-25
影响因子：
4.4
通讯作者：
Winn, Philip
中科院分区：
文献类型：
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作者：
Winn, Philip
这篇综述提出了这样一个假设，即考虑脚桥被盖核的最佳方法是通过与黑质的类比。黑质包含两个主要的部分：延髓部和网状部。前者包含在基底神经节内广泛投射的多巴胺神经元，而后者接受皮质纹状体输出。类似地，PPTg包含Ch5乙酰胆碱神经元，其投射到丘脑和皮质纹状体系统（特别是黑质的丘脑部和丘脑底核），而脚桥脑的非胆碱能神经元接收皮质纹状体输出。脚桥被盖核的位置，组成和连接的评估，以支持这一假设，它与黑质的结构相似。评估的运动，感觉和认知功能的pedunculopontine也提出，建议功能的相似性也存在。有一个明确的模型脚桥脑的结构和功能是一个重要的问题。它显然与帕金森病有关，可能成为治疗干预的目标。如果要实现这一点，最好是尽可能清楚地了解脚桥脑的结构和功能，以最大限度地发挥积极的作用。(C)2006 Elsevier B.V.保留所有权利。
This review presents the hypothesis that the best way to consider the pedunculopontine tegmental nucleus is by analogy with the substantia nigra. The substantia nigra contains two main compartments: the pars compacta and the pars reticulata. The former contains dopamine neurons that project widely within the basal ganglia while the latter is in receipt of corticostriatal output. Similarly, the PPTg contains the Ch5 acetylcholine containing neurons that project to the thalamus and corticostriatal systems (notably the pars compacta of substantia nigra and the subthalamic nucleus) while the non-cholinergic neurons of the pedunculopontine are in receipt of corticostriatal output. Assessment of the location, composition and connections of the pedunculopontine tegmental nucleus is made to support the hypothesis that it has structural similarities with substantia nigra. Assessment of the motor, sensory and cognitive functions of the pedunculopontine is also made, suggesting functional similarities exist also. Having a clear model of pedunculopontine structure and function is a matter of some importance. It is clearly involved in Parkinson's disease and could potentially be a target for therapeutic intervention. If this is to be realized it will be best to have as clear an understanding as possible of pedunculopontine structure and function in order to maximize positive benefits. (C) 2006 Elsevier B.V. All rights reserved.