Wisconsin card sorting test performance following head injury: Dorsolateral fronto-striatal circuit activity predicts perseveration
Wisconsin card sorting test performance following head injury: Dorsolateral fronto-striatal circuit activity predicts perseveration
复制标题
DOI：
10.1076/jcen.21.1.2.940
复制
发表时间：
1999-02-01
影响因子：
2.2
通讯作者：
Hommer, DW
中科院分区：
文献类型：
--
作者：
Lombardi, WJ;Andreason, PJ;Hommer, DW
威斯康星州卡片分类测验（WCST）被认为是额叶功能的敏感指标。然而，最近的几项研究未能发现该皮质区的结构损伤与测试中的持续性之间的一致关系。在本研究中，正电子发射断层扫描（PET）成像与F-18-氟脱氧葡萄糖被用来检查的关系，局部脑代谢的持续反应的WCST的历史，闭合性颅脑损伤的患者。持续反应和代谢之间的反比关系被发现在右侧，但不是左侧，背外侧前额叶皮层和尾状核。持续性反应与额叶和基底神经节的其他几个区域（包括壳核和双侧额极）的代谢无关。这些数据表明，右背外侧额叶皮层下电路的功能完整性是至关重要的WCST性能。
The Wisconsin Card Sorting Test (WCST) has been argued to be a sensitive indicator of frontal lobe function. However, several recent studies have failed to find a consistent relationship between structural damage to this cortical area and perseveration on the test. In the present study, positron emission tomography (PET) imaging with F-18-fluorodeoxyglucose was used to examine the relationship of regional brain metabolism to perseverative responding on the WCST in patients with a history of closed-head injury. An inverse relationship was found between perseverative responses and metabolism in the right, but not the left, dorsolateral prefrontal cortex and caudate nucleus. Perseverative responding was not related to metabolism in several other regions of the frontal lobes and basal ganglia, including the putamen and the frontal poles bilaterally. These data suggest that the functional integrity of the right dorsolateral frontal-subcortical circuit is critical for WCST performance.