Amygdala lesions in rhesus macaques decrease attention to threat.
Amygdala lesions in rhesus macaques decrease attention to threat.
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DOI：
10.1038/ncomms10161
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发表时间：
2015-12-14
影响因子：
16.6
通讯作者：
Averbeck BB
中科院分区：
文献类型：
--
作者：
Dal Monte O;Costa VD;Noble PL;Murray EA;Averbeck BB
动物和人类研究的证据表明，杏仁核在检测威胁和将注意力引导到眼睛方面发挥着作用。然而，目前还没有系统的研究杏仁核是否特别促进对眼睛的注意力，或者其他特征是否也可以通过杏仁核处理来驱动注意力。本研究的目的是研究恒河猴杏仁核病变对特定面部特征的注意捕获的影响，以及自由观看时的凝视模式和瞳孔扩张的变化。在这里，我们显示减少注意力捕获的威胁刺激，特别是嘴，并减少探索的眼睛在自由观看猴子杏仁核病变。我们的研究结果支持杏仁核在检测威胁信号和在自由观看不同表情时将注意力引导到面部眼睛区域中的作用。 人类和非人类灵长类动物大脑内侧颞叶中的杏仁核被认为处理显著的社会刺激并介导威胁辨别。在这里，Dal Monte等人表明，杏仁核损伤的恒河猴在检测威胁信号和将注意力引导到同种面部的眼睛区域方面存在缺陷。
Evidence from animal and human studies has suggested that the amygdala plays a role in detecting threat and in directing attention to the eyes. Nevertheless, there has been no systematic investigation of whether the amygdala specifically facilitates attention to the eyes or whether other features can also drive attention via amygdala processing. The goal of the present study was to examine the effects of amygdala lesions in rhesus monkeys on attentional capture by specific facial features, as well as gaze patterns and changes in pupil dilation during free viewing. Here we show reduced attentional capture by threat stimuli, specifically the mouth, and reduced exploration of the eyes in free viewing in monkeys with amygdala lesions. Our findings support a role for the amygdala in detecting threat signals and in directing attention to the eye region of faces when freely viewing different expressions. The amygdala in the medial temporal lobe of the human and non-human primate brain is known to process salient social stimuli and to mediate threat discrimination. Here, Dal Monte et al. show that rhesus monkeys with amygdala lesions have deficits in detecting threat signals and directing attention to the eye region of a conspecific's face.