The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men
The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men
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DOI：
10.1186/s12877-015-0169-y
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发表时间：
2015-12-21
期刊：
影响因子：
4.1
通讯作者：
Wannamethee, S. Goya
中科院分区：
文献类型：
--
作者：
Papachristou, Efstathios;Ramsay, Sheena E.;Wannamethee, S. Goya
背景：目前的研究已经确定肥胖是认知障碍的主要可改变的危险因素之一。然而，在老年人群中，关于整体和局部身体成分指标以及肌肉减少症与认知功能之间关系的证据仍然不一致。方法：数据基于英国区域心脏研究（BRHS）的1，570名参与者，该研究是一项来自1978-80年启动的24个英国城镇的英国老年男性队列，他们在2010-12年重新进行了检查，年龄71-92岁。认知功能评估与测试你的记忆认知筛选工具。使用生物电阻抗分析评估的身体组成特征包括总脂肪量（FM）、中央FM、外周FM和内脏脂肪水平。使用欧洲老年人肌肉减少症工作组（EWGSOP）对严重肌肉减少症的定义和美国国立卫生研究院基金会（FNIH）肌肉减少症项目criteria.Results：在1，570名男性中，636名（41%）被归类为轻度认知障碍（MCI），133名（8%）被归类为严重认知障碍（SCI）。经t检验校正的多项逻辑回归显示，与正常认知老化组的参与者相比，SCI患者更有可能腰围>102 cm，BMI >30 kg/m2，总FM、中央FM、外周FM和内脏脂肪水平处于上五分位，并且肌肉减少。这些关系对于总FM仍然是显著的（RR = 2.16，95% CI 1.29-3.63），中央FM（RR = 1.85，95% CI 1.09-3.14），外周FM（RR = 2.67，95%CI 1.59-4.48），内脏脂肪水平（RR = 2.28，95% CI 1.32-3.94），BMI（RR = 2.25，95% CI 1.36-3.72）和腰围（RR = 1.63，95%CI 1.05-2.55）调整酒精、吸烟、社会阶层、体力活动和心血管疾病或糖尿病史后。在进一步调整白细胞介素-6和胰岛素抵抗，中央FM，腰围和肌肉减少不再显着相关SCI.Conclusions：外周FM，内脏脂肪水平，BMI水平的增加与老年人SCI。不同的病理生理机制将区域脂肪组织沉积和认知功能联系起来。
Background: Current research has established obesity as one of the main modifiable risk factors for cognitive impairment. However, evidence on the relationships of total and regional body composition measures as well as sarcopenia with cognitive functioning in the older population remains inconsistent.Methods: Data are based on 1,570 participants from the British Regional Heart Study (BRHS), a cohort of older British men from 24 British towns initiated in 1978-80, who were re-examined in 2010-12, aged 71-92 years. Cognitive functioning was assessed with the Test-Your-Memory cognitive screening tool. Body composition characteristics assessed using bioelectrical impedance analysis included total fat mass (FM), central FM, peripheral FM, and visceral fat level. Sarcopenia was defined using the European Working Group on Sarcopenia in Older People (EWGSOP) definition of severe sarcopenia and the Foundation for the National Institutes of Health (FNIH) sarcopenia project criteria.Results: Among 1,570 men, 636 (41 %) were classified in the mild cognitive impairment (MCI) and 133 (8 %) in the severe cognitive impairment (SCI) groups. Age-adjusted multinomial logistic regressions showed that compared with participants in the normal cognitive ageing group, those with SCI were more likely to have waist circumference >102 cm, BMI >30 kg/m(2), to be in the upper quintile of total FM, central FM, peripheral FM and visceral fat level and to be sarcopenic. The relationships remained significant for total FM (RR = 2.16, 95 % CI 1.29-3.63), central FM (RR = 1.85, 95 % CI 1.09-3.14), peripheral FM (RR = 2.67, 95 % CI 1.59-4.48), visceral fat level (RR = 2.28, 95 % CI 1.32-3.94), BMI (RR = 2.25, 95 % CI 1.36-3.72) and waist circumference (RR = 1.63, 95 % CI 1.05-2.55) after adjustments for alcohol, smoking, social class, physical activity and history of cardiovascular diseases or diabetes. After further adjustments for interleukin-6 and insulin resistance, central FM, waist circumference and sarcopenia were no longer significantly associated with SCI.Conclusions: Increased levels of peripheral FM, visceral fat level, and BMI are associated with SCI among older people. Distinct pathophysiological mechanisms link regional adipose tissue deposition and cognitive functioning.