ADULT DIETARY-INTAKE AND PROSTATE-CANCER RISK IN UTAH - A CASE-CONTROL STUDY WITH SPECIAL EMPHASIS ON AGGRESSIVE TUMORS
ADULT DIETARY-INTAKE AND PROSTATE-CANCER RISK IN UTAH - A CASE-CONTROL STUDY WITH SPECIAL EMPHASIS ON AGGRESSIVE TUMORS
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DOI：
10.1007/bf00053126
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发表时间：
1991-03-01
影响因子：
2.3
通讯作者：
MAHONEY, AW
中科院分区：
文献类型：
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作者：
WEST, DW;SLATTERY, ML;MAHONEY, AW
在犹他州进行的一项基于人群的病例对照研究中，对1984年至1985年诊断为前列腺癌的358例患者和按年龄和居住县分类匹配的679例对照进行了访谈，以调查膳食能量（kcal）、脂肪、蛋白质、维生素A、β-胡萝卜素、维生素C、锌、镉、硒摄入量与前列腺癌之间的关系。 饮食数据采用定量食物频率问卷调查。 数据分别按年龄（45-67岁，68-74岁）和肿瘤侵袭性进行分析。 最显著的相关性见于老年男性和侵袭性肿瘤。 膳食脂肪是这些男性最强的风险因素，比值比（OR）为2.9总脂肪（95%置信区间[CI] 1.0-8.4）; OR = 2.2（CI = 0.7-6.6）;单不饱和脂肪OR = 3.6（CI = 1.3-9.7）;多不饱和脂肪OR = 2.7（CI = 1.1-6.8）。 蛋白质和碳水化合物有积极的，但不显着的协会。 能量摄入的OR为2.5（CI = 1.0-6.5）。 在这些老年男性中，饮食胆固醇，体重或体力活动没有影响。 前列腺癌与锌、镉、硒、维生素C和β-胡萝卜素的饮食摄入量之间几乎没有联系。 总维生素A与所有前列腺癌都有轻微的正相关（OR = 1.6，CI = 0.9-2.4），但与侵袭性肿瘤无关。 在年轻男性中没有发现相关性，除了体育活动显示活跃的男性患侵袭性肿瘤的风险增加但不显著（OR = 2.0，CI = 0.8-5.2）和β-胡萝卜素显示不显著的保护作用（OR = 0.6，CI = 0.3-1.6）。 研究结果表明，饮食摄入，特别是脂肪，可能会增加老年男性患侵袭性前列腺肿瘤的风险。
A population-based case-control study in Utah of 358 cases diagnosed with prostate cancer between 1984 and 1985, and 679 controls categorically matched by age and county of residence, were interviewed to investigate the association between dietary intake of energy (kcal), fat, protein, vitamin A, beta-carotene, vitamin C, zinc, cadmium, selenium, and prostate cancer. Dietary data were ascertained using a quantitative food-frequency questionnaire. Data were analyzed separately by age (45-67, 68-74) and by tumor aggressiveness. The most significant associations were seen for older males and aggressive tumors. Dietary fat was the strongest risk factor for these males, with an odds ratio (OR) of 2.9 (95 percent confidence interval [CI] 1.0-8.4) for total fat; OR = 2.2 (CI = 0.7-6.6) for saturated fat; OR = 3.6 (CI = 1.3-9.7) for monounsaturated fat; and OR = 2.7 (CI = 1.1-6.8) for polyunsaturated fat. Protein and carbohydrates had positive but nonsignificant associations. Energy intake had an OR of 2.5 (CI = 1.0-6.5). In these older men, no effects were seen for dietary cholesterol, body mass, or physical activity. There was little association between prostate cancer and dietary intake of zinc, cadmium, selenium, vitamin C, and beta-carotene. Total vitamin A had a slight positive association with all prostate cancer (OR = 1.6, CI = 0.9-2.4), but not with aggressive tumors. No associations were found in younger males, with the exception of physical activity which showed active males to be at an increased but nonsignificant risk for aggressive tumors (OR = 2.0, CI = 0.8-5.2) and beta-carotene which showed a nonsignificant protective effect (OR = 0.6, CI = 0.3-1.6). The findings suggest that dietary intake, especially fats, may increase risk of aggressive prostate tumors in older males.