THE EFFECT OF ULTRASOUND ON THE INVITRO PENETRATION OF IBUPROFEN THROUGH HUMAN-EPIDERMIS
THE EFFECT OF ULTRASOUND ON THE INVITRO PENETRATION OF IBUPROFEN THROUGH HUMAN-EPIDERMIS
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DOI：
10.1023/a:1015938522673
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发表时间：
1989-08-01
影响因子：
3.7
通讯作者：
SIEGEL, F
中科院分区：
文献类型：
--
作者：
BRUCKS, R;NANAVATY, M;SIEGEL, F
本研究的目的是建立一种体外方法，以考察超声波对丙二醇水载体剂中布洛芬通过人体表皮的体外吸收的影响。一个扩散池被改装，这样超声波就可以应用到车辆和皮肤上。由于超声波可以提高应用区域下的温度，因此可以同时控制代表温度效应的超声波实验。结果表明，超声波能增加布洛芬在人体皮肤中的渗透率。扩散的这种增加比使用等量温度增加的对照组要大。研究结果还表明，载药成分的蒸发可改变皮肤/载药分配系数，从而降低超声波对布洛芬透皮吸收的影响。
The objective of this study was to develop an in vitro method to investigate the effect of ultrasound on the in vitro absorption of ibuprofen from a propylene glycol/water vehicle through human epidermis. A diffusion cell was modified so ultrasound could be applied to the vehicle and skin. Since ultrasound can increase the temperature underneath the area of application, control representing temperature effects can concurrently to the ultrasound experiment. The results demonstrate that ultrasound can increase the penetration of ibuprofen through human skin. This increase in diffusion was greater than for controls where an equivalent increase in temperature was utilized. The results also indicate that evaporation of vehicle components may alter the skin/vehicle partition coefficient, decreasing the effects of ultrsound on the penetration of ibuprofen through the skin.