Reduction of the cAMP response to norepinephrine in rat cerebral cortex following repeated restraint stress.
Reduction of the cAMP response to norepinephrine in rat cerebral cortex following repeated restraint stress.
复制标题
重复束缚应激后大鼠大脑皮层 cAMP 对去甲肾上腺素的反应减少。
DOI：
10.1007/bf00427695
复制
发表时间：
1984
影响因子：
3.4
通讯作者：
Slucky,AV
中科院分区：
文献类型：
--
作者：
Stone,EA;Platt,JE;Trullas,R;Slucky,AV
The present studies examined the effect of restraint stress on the sensitivity of the catecholamine-cAMP generating system in the rat cerebral cortex. Restraint was found to cause a persistent reduction in the magnitude of the cAMP response to catecholamines. This effect occurred after repeated but not acute stress and was more marked with twice-daily as compared to once-daily treatment. The reduction in response was more marked with norepinephrine than with isoproterenol, indicating a selective action of stress on the non-β component of the noradrenergic response. The findings suggest that subsensitivity of the cAMP response to norepinephrine is a general response to chronic stressful stimuli and may be related to the action of certain antidepressant agents.
