Bradycardia is associated with future cardiovascular diseases and death in men from the general population
Bradycardia is associated with future cardiovascular diseases and death in men from the general population
复制标题
DOI：
10.1016/j.atherosclerosis.2014.06.024
复制
发表时间：
2014-09-01
期刊：
影响因子：
5.3
通讯作者：
Nakamura, Motoyuki
中科院分区：
文献类型：
--
作者：
Makita, Shinji;Onoda, Toshiyuki;Nakamura, Motoyuki
背景：虽然较高的心率是心血管疾病(CVD)事件的危险因素，但还没有关于心动过缓的报道。一项基于社区的前瞻性队列研究中，研究了静息脉搏频率(RPR)的降低和升高是否与心血管风险相关。方法：排除房颤患者、有心血管病史的患者和接受降压治疗的患者后，17766名受试者(5958名男性)年龄40-79岁(平均61.5岁)。使用连续两次测量的平均值，将基线时的RPR分为四组(RPR；60，60-69.5，70-79.5，=80次/分钟(Bpm))。终点设定为心肌梗死、中风或猝死的综合结果。结果：在平均5.6年的随访中，男性发生213起事件，女性发生186起事件。在COX回归模型中，RPR=80次/分的男性组与RPR为60-69.5次/分的对照组相比，心血管疾病的风险增加(危险比[HR]=1.73p=0.005和HR=2.01p<；0.001)。即使在调整了年龄和其他心血管危险因素(HR=1.55，P=0.026，RPR=80次/分)后，仍发现这些风险增加。在女性中，RPR和心血管疾病风险之间没有显著的关联。结论：在看似健康的男性中，心动过缓和较高的脉率可能是未来心血管事件的独立危险因素。(C)2014爱思唯尔爱尔兰有限公司。保留所有权利。
Background: Although a higher heart rate is known to be a risk factor for cardiovascular disease (CVD) events, there have been no reports concerning bradycardia. Whether lower and higher resting pulse rates (RPRs) are associated with cardiovascular risk was investigated in subjects from a community-based, prospective cohort study.Methods: After subjects with atrial fibrillation, subjects with a history of CVD, and subjects receiving antihypertensive treatment were excluded, 17,766 subjects (5958 men), aged 40-79 (mean 61.5) years, were analyzed. The RPR at baseline was categorized into four groups (RPR< 60, 60-69.5, 70-79.5, >= 80 beats per minute (bpm)) using the average value of two consecutive measurements. The endpoint was set as the composite outcome of myocardial infarction, stroke, or sudden death.Results: During a mean follow up of 5.6 years, there were 213 events in men and 186 events in women. In Cox regression models, increased risks of CVD were found in the men group with RPR= 80 bpm, compared with the reference group with RPR 60-69.5 bpm (hazard ratio [HR] = 1.73, p = 0.005 and HR = 2.01, p < 0.001). These increased risks were found even when adjusted for age and other CVD risk factors (HR = 1.55, p = 0.026 with RPR= 80 bpm). In women, there were no significant associations between RPR and CVD risk.Conclusion: Bradycardia, as well as a higher pulse rate, may be an independent risk factor for future cardiovascular events in apparently healthy men. (C) 2014 Elsevier Ireland Ltd. All rights reserved.