Imaging of Polyethylene Glycol Layers on Nanoparticles
Imaging of Polyethylene Glycol Layers on Nanoparticles
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纳米粒子上的聚乙二醇层成像
DOI：
10.1017/s1431927615001956
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发表时间：
2015
影响因子：
2.8
通讯作者：
U. Baxa
中科院分区：
文献类型：
--
作者：
Sarah R. Anderson;Mackensie C. Smith;J. Clogston;A. Patri;S. McNeil;U. Baxa
通过在纳米颗粒表面添加聚乙二醇（PEG）（聚乙二醇化）来包裹纳米颗粒是一种重要的方法，可以保护它们免受免疫系统和网状内皮系统的摄取。PEG的加入产生了具有所谓“隐形”行为的纳米颗粒，显著增加了循环时间，减少了聚集行为，减少了与非靶向血清和组织蛋白[2]的相互作用。由于长亲水性乙二醇重复序列，聚乙二醇涂层也增加了纳米颗粒在血清和缓冲液中的溶解度。聚乙二醇链的长度可以根据应用选择，其末端通常被修饰为在一端附着纳米颗粒，另一端通常有一个甲氧基。
The encapsulation of nanoparticles by adding polyethylene glycol (PEG) to their surface (PEGylation) is an important method to protect them from the immune system and from uptake by the reticuloendothelial system [1]. The addition of PEG creates nanoparticles with so-called “stealth” behavior that have significantly increased circulation times, reduced aggregation behavior, and less interaction with non-targeted serum and tissue proteins [2]. The PEG coating also increases solubility of nanoparticles in serum and buffer due to the long hydrophilic ethylene glycol repeats. The length of the PEG chain can be chosen according to application and the ends are usually modified for nanoparticle attachment on one end and often have a methoxy group on the other end.