Role of Paralogue of XRCC4 and XLF in DNA Damage Repair and Cancer Development.
Role of Paralogue of XRCC4 and XLF in DNA Damage Repair and Cancer Development.
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DOI：
10.3389/fimmu.2022.852453
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发表时间：
2022
影响因子：
7.3
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Tang J;Li Z;Wu Q;Irfan M;Li W;Liu X
非同源末端连接（Non-homologous end joining，cNHEJ）是修复DNA双链断裂（double-strand breaks，DSB）的主要途径。几个核心cNHEJ参与修复过程，如KU 70和80，DNA依赖性蛋白激酶催化亚基（DNA-PKcs），Artemis，X射线修复交叉互补蛋白4（XRCC 4），DNA连接酶IV和XRCC 4样因子（XLF）。最近的研究在cNHEJ过程中增加了许多新的蛋白质。新鉴定的蛋白质之一是XRCC 4和XLF的Parkinson（PAXX），其充当在DSB位点稳定KU 70/80异二聚体所需的支架，并促进cNHEJ机器的组装和/或稳定性。PAXX在XLF缺陷背景下的淋巴细胞发育中起重要作用，而XLF/PAXX双缺陷小鼠胚胎在出生前死亡。新出现的证据还显示PAXX的表达水平与人类患者的癌症发展之间存在联系，表明该蛋白质的预后作用。本文就PAXX在DSB修复中的作用及其在肿瘤发生发展中的作用作一综述。
Non-homologous end joining (cNHEJ) is a major pathway to repair double-strand breaks (DSBs) in DNA. Several core cNHEJ are involved in the progress of the repair such as KU70 and 80, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Artemis, X-ray repair cross-complementing protein 4 (XRCC4), DNA ligase IV, and XRCC4-like factor (XLF). Recent studies have added a number of new proteins during cNHEJ. One of the newly identified proteins is Paralogue of XRCC4 and XLF (PAXX), which acts as a scaffold that is required to stabilize the KU70/80 heterodimer at DSBs sites and promotes the assembly and/or stability of the cNHEJ machinery. PAXX plays an essential role in lymphocyte development in XLF-deficient background, while XLF/PAXX double-deficient mouse embryo died before birth. Emerging evidence also shows a connection between the expression levels of PAXX and cancer development in human patients, indicating a prognosis role of the protein. This review will summarize and discuss the function of PAXX in DSBs repair and its potential role in cancer development.
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影响因子：
16
作者：
Callen, Elsa;Jankovic, Mila;Wong, Nancy;Zha, Shan;Chen, Hua-Tang;Difilippantonio, Simone;Di Virgilio, Michela;Heidkamp, Gordon;Alt, Frederick W.;Nussenzweig, Andre;Nussenzweig, Michel
通讯作者：
Nussenzweig, Michel
DOI：
10.1016/s0921-8777(98)00063-9
发表时间：
1999-01-26
期刊：
MUTATION RESEARCH-DNA REPAIR
影响因子：
--
作者：
Bryans, M;Valenzano, MC;Stamato, TD
通讯作者：
Stamato, TD
影响因子：
4.8
作者：
Callebaut, Isabelle;Malivert, Laurent;de Villartay, Jean-Pierre
通讯作者：
de Villartay, Jean-Pierre
影响因子：
14.9
作者：
Chang HH;Lieber MR
通讯作者：
Lieber MR
影响因子：
16
作者：
Ciccia A;Elledge SJ
通讯作者：
Elledge SJ