Pancreatic circulation: intrinsic regulation.
Pancreatic circulation: intrinsic regulation.
复制标题
胰腺循环：内在调节。
DOI：
10.1152/ajpgi.1982.242.6.g596
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Granger,DN
中科院分区：
文献类型：
--
作者：
Kvietys,PR;McLendon,JM;Bulkley,GB;Perry,MA;Granger,DN
本研究的目的是表征在完全分离的，灌注的犬胰腺中涉及的血流和氧合调节的内在机制。在分级动脉压降低和静脉压升高期间测量动脉压、静脉流出压、血流量、动静脉氧差和毛细血管滤过系数。动脉压降低导致胰腺血流量和血管阻力降低，而静脉压升高导致血流量减少和血管阻力增加。动脉和静脉压改变引起的血流量减少与氧提取和毛细血管滤过系数增加有关。在相同的压力扰动期间，氧摄取在40-100 ml.min-1.100 g-1的血流量之间保持恒定，但随着血流量降低到40 ml.min-1.100 g-1以下而逐渐降低。动脉闭塞导致闭塞后反应性充血，其程度与闭塞时间有关。这项研究的结果表明，胰腺血流量的内在调节可以归因于代谢和生肌机制。阻力血管和交换血管似乎都在调节胰腺实质的氧输送中起作用。
The purpose of the present study was to characterize the intrinsic mechanisms involved in the regulation of blood flow and oxygenation in the totally isolated, perfused canine pancreas. Arterial pressure, venous outflow pressure, blood flow, arteriovenous oxygen difference, and capillary filtration coefficient were measured during graded arterial pressure reductions and venous pressure elevation. Reductions in arterial pressure caused pancreatic blood flow and vascular resistance to decrease, whereas venous pressure elevation resulted in a decreased blood flow and increased vascular resistance. The reductions in blood flow produced by arterial and venous pressure alterations were associated with increases in oxygen extraction and capillary filtration coefficient. During the same pressure perturbations, oxygen uptake remained constant between blood flows of 40-100 ml.min-1.100 g-1, yet decreased progressively as blood flow was reduced below 40 ml.min-1.100 g-1. Arterial occlusion resulted in a postocclusive reactive hyperemia, the magnitude of which was related to the duration of occlusion. The findings of this study suggest that intrinsic regulation of pancreatic blood flow can be attributed to both metabolic and myogenic mechanisms. Resistance and exchange vessels both appear to play a role in the regulation of oxygen delivery to the pancreatic parenchyma.