Early postoperative response of cytokines in liver transplant recipients
Early postoperative response of cytokines in liver transplant recipients
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DOI：
10.1016/j.transproceed.2006.08.054
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发表时间：
2006-10-01
影响因子：
0.9
通讯作者：
Ferron, J. A.
中科院分区：
文献类型：
--
作者：
Hassan, L.;Bueno, P.;Ferron, J. A.
我们评估了肝移植前 (T-0) 以及术后 1、6、12 小时和 1、2、3、5 和 7 天几种细胞因子（IL-2、IL-4、IL-6、IL-10、TNF-α、IFN-γ）的早期术后反应。细胞因子浓度与血清胆红素水平相关，作为术后并发症的预测因子。对 16 名年龄 43 至 61 岁的肝移植受者（13 名男性，3 名女性）的血浆样本中的细胞因子水平进行了测定。 IL-6和IL-10在移植后1小时达到最大浓度。 IL-6 的每次增加都与 IL-10 的增加相关。 IL-2、IL-4、TNF-α 和 IFN-γ 对于每个研究的患者都有特定的时间进程。胆红素降至几乎正常值，但在发生术后并发症的情况下则不然，其中 IL-6 的值比未出现术后并发症的肝移植受者的值高出四倍。 IL-6 和 IL-10 血浆浓度和血清胆红素水平可能可作为肝移植受者术后并发症的预测因素。
We evaluated the early postoperative response of several cytokines (IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma) prior to liver transplantation (T-0) as well as 1, 6, and 12 hours and 1, 2, 3, 5, and 7 days afterward. Cytokine concentrations were correlated with serum levels of bilirubin as a predictor of postoperative complications. Cytokine levels were determined in plasma samples from 16 liver transplant recipients (13 men, 3 women) aged 43 to 61 years. IL-6 and IL-10 reached their maximum concentrations 1 hour after transplantation. Each increase in IL-6 correlated to a rise in IL-10. IL-2, IL-4, TNF-alpha, and IFN-gamma had a particular time-course for each patient studied. Bilirubin fell to almost normal values but not in cases of postoperative complications, where IL-6 showed values four times higher compared to those of liver transplant recipients who did not show postoperative complications. IL-6 and IL-10 plasma concentrations and serum bilirubin level might be useful as a predictive factor of postoperative complications in liver transplant recipients.