Photoreception and circadian clock system of the chicken pineal gland
Photoreception and circadian clock system of the chicken pineal gland
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DOI：
10.1002/jemt.1070
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发表时间：
2001-04-01
影响因子：
2.5
通讯作者：
Fukada, Y
中科院分区：
文献类型：
--
作者：
Okano, T;Fukada, Y
鸡松果体细胞包含生物钟系统的三个主要组成部分：1)一个自我维持的振荡器，2)到振荡器的光输入途径，3)一个显性；褪黑素的节律性产生所代表的输出即使在分离的松果体或分离的松果体细胞的培养条件下，输入-振荡-输出功能也得到了很好的维持。由于这些实验优势，鸡松果体已成为研究生物钟系统的最佳模型之一。自从发现松果体特异性光导分子pinopsin以来，我们已经表征了松果体细胞的内源性光传导途径。另一方面，尽管鸡松果体的研究历史悠久，但松果体时钟振荡的分子机制在很大程度上是未知的。我们最近对小鸡松果体时钟基因的表征强烈表明，它们构成了一个基于转录/翻译的自调节反馈回路，这与哺乳动物SCN中产生昼夜节律性非常相似。Microsc。科学技术学报，2002。(C) 2001 Wiley-Liss, Inc。
Chicken pinealocytes contain three major components of the circadian clock system: 1) a self-sustained oscillator, 2) a photic-input pathway to the oscillator, and 3) an overt; output represented by the rhythmic production of melatonin. Even under cultured conditions of isolated pineal gland or dissociated pinealocytes, the input-oscillator-output functions are well maintained. Because of these experimental advantages, chicken pineal gland has been one of the best models for the study of the circadian clock system. Since the finding of a pineal-specific photoreceptive molecule, pinopsin, we have characterized the endogenous phototransduction pathway in the pinealocytes. On the other hand, despite the long history of chick pineal research, the molecular mechanism underlying the pineal clock oscillation has been largely unknown. Our recent characterization of the chick pineal clock genes strongly suggests that they constitute a transcription/translation-based autoregulatory feedback loop, which is very similar to that generating circadian rhythmicity in mammalian SCN. Microsc. Res. Tech. 53:72-80, 2002. (C) 2001 Wiley-Liss, Inc.