17β-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids
17β-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids
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DOI：
10.1097/00000539-200106000-00033
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发表时间：
2001-06-01
影响因子：
5.7
通讯作者：
Jiang, H
中科院分区：
文献类型：
--
作者：
Chen, JF;Xu, WR;Jiang, H
我们研究了17 β-雌二醇对缺血诱导的沙鼠海马CA 1区细胞外氨基酸（天冬氨酸，谷氨酸，甘氨酸和牛磺酸）增加的影响，通过微透析-高效液相色谱系统在体内。短暂性前脑缺血3分钟产生了明显的积累天冬氨酸，谷氨酸，牛磺酸和甘氨酸（498%，410%，266%，和178%，分别）。17 β-雌二醇使天冬氨酸和谷氨酸的增加减少了峰值的57%和53%。这一发现表明，17 β-雌二醇可能通过减弱缺血诱导的细胞外兴奋性氨基酸的增加来保护神经元免受缺血损伤。
We studied the effect of 17 beta -estradiol on ischemia-induced increases in extracellular amino acids (aspartate, glutamate, glycine, and taurine) in the gerbil hippocampal CA1 region by a microdialysis-high-performance Liquid chromatography system in vivo. Transient forebrain ischemia for 3 min produced a marked accumulation of aspartate, glutamate, taurine, and glycine (498%, 410%, 266%, and 178%, respectively). 17 beta -estradiol reduced the increase of aspartate and glutamate by 57% and 53% of the peak values. This finding suggests that 17 beta -estradiol may protect neurons against ischemic damage by attenuating the ischemia-induced increase in extracellular excitatory amino acids.