Biodegradable Zwitterionic Cream Gel for Effective Prevention of Postoperative Adhesion
Biodegradable Zwitterionic Cream Gel for Effective Prevention of Postoperative Adhesion
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可生物降解的两性离子霜凝胶可有效预防术后粘连
DOI：
10.1002/adfm.202009431
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发表时间：
2020
影响因子：
19
通讯作者：
Cao, Zhiqiang
中科院分区：
文献类型：
--
作者：
Zhang, Ershuai;Yang, Jianhai;Wang, Ke;Song, Boyi;Zhu, Hui;Han, Xiangfei;Shi, Yuanjie;Yang, Chengbiao;Zeng, Zhipeng;Cao, Zhiqiang
术后腹膜粘连是几乎所有类型腹部和盆腔手术的常见并发症。这导致了许多医疗问题和巨大的经济负担的病人。目前的防粘连策略主要集中在物理屏障上，包括薄膜和水凝胶。然而，它们只能在一定程度上减轻或减少粘连，并且它们的应用过程远不理想。这项工作报告了一种可生物降解的两性离子乳膏凝胶的开发，该凝胶具有理想抗粘连材料的一系列特性，包括独特的可注射但可延展和自支撑特性，可立即局部应用，无需固化，等待或冲洗，无需止血，蛋白质/细胞抗性和生物降解性。乳膏凝胶通过在大鼠模型中完全可靠地预防原发性和更严重的复发性粘连，显示出抗粘连功效的重大进步。
Postoperative peritoneal adhesions are frequent complications for almost any type of abdominal and pelvic surgery. This leads to numerous medical problems and a huge financial burden to the patients. Current anti‐adhesion strategies focus mostly on physical barriers including films and hydrogels. However, they can only alleviate or reduce adhesions to a certain level and their applying processes are far from ideal. This work reported the development of a biodegradable zwitterionic cream gel presenting a series of characters for an ideal anti‐adhesion material, including unique injectable yet malleable and self‐supporting properties, which enables an instant topical application, no curing, waiting, or suturing, no hemostasis requirement, protein/cell resistance, and biodegradability. The cream gel shows a major advancement in anti‐adhesion efficacy by completely and reliably preventing a primary and more severe recurrent adhesion in rat models.