The combined effect of vitamin D and parathyroid hormone concentrations on glucose homeostasis in older patients with prediabetes: A cross-sectional study
The combined effect of vitamin D and parathyroid hormone concentrations on glucose homeostasis in older patients with prediabetes: A cross-sectional study
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DOI：
10.1177/1479164117738443
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发表时间：
2018-03-01
影响因子：
2.4
通讯作者：
Kotsa, Kalliopi
中科院分区：
文献类型：
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作者：
Karras, Spyridon N.;Anagnostis, Panagiotis;Kotsa, Kalliopi
背景：维生素D和甲状旁腺激素对葡萄糖稳态的联合作用尚未得到充分研究。本研究的目的是探讨甲状旁腺激素/维生素D轴对葡萄糖稳态的作用，在老年人前驱diabetes.Methods：糖尿病前期患者（n=144）和健康的年龄匹配的对照组（n=81）包括在这个横断面研究。研究参数包括人体测量特征、早晨空腹血糖（空腹血浆葡萄糖）、胰岛素（空腹血浆胰岛素）、甲状旁腺激素、25-羟基维生素D、胰岛素抵抗的稳态模型评估和细胞功能的稳态模型评估。根据维生素D状态和甲状旁腺激素的三分位数，两组均分为亚组。结果：两组在体重指数，25-羟基维生素D和甲状旁腺激素状态方面具有可比性。在糖尿病前期组中，甲状旁腺激素三分位数之间的空腹血糖差异显著，从第一到第三个三分位数增加（p=0.011）。有较高的空腹血糖值的参与者与维生素D缺乏/甲状旁腺激素第三三个三分位数相比，所有其他groups（p=0.031，0.027和0.039，分别）。结论：甲状旁腺激素状态与葡萄糖稳态受损;维生素D缺乏症D结合高甲状旁腺激素浓度与糖尿病前期老年患者的血糖失调。
Background: The combined effect of vitamin D and parathyroid hormone on glucose homeostasis has not been adequately investigated. The aim of this study was to examine the role of parathyroid hormone/vitamin D axis on glucose homeostasis in elderly persons with prediabetes.Methods: Patients with prediabetes (n=144) and healthy age-matched controls (n=81) were included in this cross-sectional study. Study parameters included anthropometric characteristics, morning fasting glucose (fasting plasma glucose), insulin (fasting plasma insulin), parathyroid hormone, 25-hydroxyvitamin D, homeostasis model assessment of insulin resistance and homeostasis model assessment of -cell function. Both groups were stratified into subgroups according to vitamin D status and tertiles of parathyroid hormone.Results: Both groups were comparable in terms of body mass index, 25-hydroxyvitamin D and parathyroid hormone status. In the prediabetes group, fasting plasma glucose differed significantly across parathyroid hormone tertiles, increasing from the first to the third tertile (p=0.011). There were higher fasting plasma glucose values in participants with vitamin D deficiency/parathyroid hormone third tertile compared to all other groups (p=0.031, 0.027 and 0.039, respectively).Conclusion: Parathyroid hormone status is associated with impaired glucose homeostasis; hypovitaminosis D combined with high parathyroid hormone concentrations are associated with glycaemic dysregulation in elderly patients with prediabetes.