Cdc14 plans autophagy for meiotic cell divisions.
Cdc14 plans autophagy for meiotic cell divisions.
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Cdc14 计划通过自噬来进行减数分裂细胞分裂。
DOI：
10.1080/15548627.2022.2080956
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发表时间：
2022
期刊：
影响因子：
13.3
通讯作者：
Wang,Fei
中科院分区：
文献类型：
--
作者：
Feng,Wenzhi;Argüello-Miranda,Orlando;Qian,Suhong;Wang,Fei
减数分裂蛋白酶体介导的降解作用已被广泛研究。与此同时，巨噬/自噬作为减数分裂进程的重要调节因子直到最近才出现。我们最近的出版物表明，减数分裂细胞的自噬表现出一种不同于静息细胞或有丝分裂细胞在长时间饥饿下的时间模式。重要的是，在减数分裂细胞分裂期间，即减数分裂I和减数分裂II，自噬活性振荡，这可以加速减数分裂进程，提高产孢效率。Ourin vitroandin体内实验显示，保守的磷酸酶Cdc14在减数分裂期间刺激自噬的启动，特别是在后期I和II，当一个活跃的Cdc14亚群迁移到细胞质并与吞噬细胞组装位点（PAS）相互作用时，触发Atg13的去磷酸化，以刺激Atg1激酶活性和自噬。总之，我们的发现揭示了在减数分裂过程中自噬活动的协调机制。
The role of meiotic proteasome-mediated degradation has been extensively studied. At the same time, macroautophagy/autophagy only emerged recently as an essential regulator for meiosis progression. Our recent publication showed that autophagy in meiotic cells exhibits a temporal pattern distinct from that in quiescent cells or mitotic cells under prolonged starvation. Importantly, autophagic activity oscillates during meiotic cell divisions, i.e., meiosis I and meiosis II, which can accelerate meiotic progression and increase sporulation efficiency. Ourin vitroandin vivoassays revealed that the conserved phosphatase Cdc14 stimulates autophagy initiation during meiotic divisions, specifically in anaphase I and II, when a subpopulation of active Cdc14 relocates to the cytosol and interacts with phagophore assembly sites (PAS) triggering the dephosphorylation of Atg13 to stimulate Atg1 kinase activity and autophagy. Together, our findings reveal a mechanism for the coordination of autophagy activity in the context of meiosis progression.