A Compartmental Lateral Inhibition System to Generate Contrasting Patterns.
A Compartmental Lateral Inhibition System to Generate Contrasting Patterns.
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DOI：
10.1109/lls.2015.2446211
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发表时间：
2015-06
期刊：
影响因子：
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通讯作者：
Arcak M
中科院分区：
文献类型：
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作者：
Rufino Ferreira AS;Hsia J;Arcak M
我们提出了一个侧抑制系统，并分析了基因表达的对比模式。该系统由一组通过通道相互连接的隔间组成。每个隔室包含一群细胞，这些细胞产生可扩散的分子，以便被邻近的菌落检测到。每个细胞都配备了抑制回路，当检测到的信号足够强时，抑制回路会减少其产生。我们描述了出现稳态模式的参数范围。
We propose a lateral inhibition system and analyze contrasting patterns of gene expression. The system consists of a set of compartments interconnected by channels. Each compartment contains a colony of cells that produce diffusible molecules to be detected by the neighboring colonies. Each cell is equipped with an inhibitory circuit that reduces its production when the detected signal is sufficiently strong. We characterize the parameter range in which steady-state patterns emerge.