Relaxivity of Ferumoxytol at 1.5 T and 3.0 T
Relaxivity of Ferumoxytol at 1.5 T and 3.0 T
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DOI：
10.1097/rli.0000000000000434
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发表时间：
2018-05-01
影响因子：
6.7
通讯作者：
Reeder, Scott B.
中科院分区：
文献类型：
--
作者：
Knobloch, Gesine;Colgan, Timothy;Reeder, Scott B.
目的：本研究的目的是确定的弛豫特性ferumoxytol，一个标签外的替代钆基造影剂，在生理条件下，在1.5 T和3.0 T。材料和方法：Ferumoxytol稀释在逐渐增加的浓度（0.26-4.2 mM）在生理盐水，人血浆和人全血。在37 ℃、1.5 T和3.0 T下进行磁共振弛豫测量。纵向和横向弛豫速率常数（R1，R2，R2*）测量为ferumoxytol浓度的函数，和弛豫率（r1，r2，r2*）。R1，R2，在生理盐水和血浆中发现了对ferumoxytol浓度的R2和R2*，在3.0 T下R1值较低，在1.5 T和3.0 T下R2和R2* 值相似（1.5 T：r1（生理盐水）= 19.9 2.3 s（-1）mM（-1）; r1（血浆）= 19.0 +/- 1.7 s（-1）mM（-1）; r2（生理盐水）= 60.8 +/- 3.8 s（-1）mM（-1）; r2（血浆）= 64.9 +/- 1.8 s（-1）mM（-1）; r2*（生理盐水）= 60.4 +/- 4.7 s（-1）mM（-1）; r2*（血浆）= 64.4 +/- 2.5 s（-1）mM（-1）; 3.0 T：r1（生理盐水）= 10.0 +/- 0.3 s（-1）mM（-1）; r1（血浆）= 9.5 +/- 0.2 s（-1）mM（-1）; r2（生理盐水）= 62.3 +/- 3.7 s（-1）mM（-1）; r2（血浆）= 65.2 +/- 1.8 s（-1）mM（-1）; r2*（生理盐水）= 57.0 +/- 4.7 s（-1）mM（-1）; r2*（血浆）= 55.7 +/- 4.4 s（-1）mM（-1））。弛豫速率与血药浓度呈非线性关系。从二阶多项式拟合的弛豫速率的公式计算表征R1（血液）和R2（血液）与ferumoxytol.Conclusions之间的关系：Ferumoxytol表现出较强的纵向和横向弛豫。意识到血液中ferumoxytol的非线性弛豫行为对于ferumoxytol增强的磁共振成像应用和方案优化是重要的。
Objectives: The aim of this study was to determine the relaxation properties of ferumoxytol, an off-label alternative to gadolinium-based contrast agents, under physiological conditions at 1.5 T and 3.0 T.Materials and Methods: Ferumoxytol was diluted in gradually increasing concentrations (0.26-4.2 mM) in saline, human plasma, and human whole blood. Magnetic resonance relaxometry was performed at 37 degrees C at 1.5 T and 3.0 T. Longitudinal and transverse relaxation rate constants (R1, R2, R2*) were measured as a function of ferumoxytol concentration, and relaxivities (r1, r2, r2*) were calculated.Results: A linear dependence of R1, R2, and R2* on ferumoxytol concentration was found in saline and plasma with lower R1 values at 3.0 T and similar R2 and R2* values at 1.5 T and 3.0 T (1.5 T: r1(saline) = 19.9 2.3 s(-1)mM(-1); r1(plasma) = 19.0 +/- 1.7 s(-1)mM(-1); r2(saline) = 60.8 +/- 3.8 s(-1)mM(-1); r2(plasma) = 64.9 +/- 1.8 s(-1)mM(-1); r2*(saline) = 60.4 +/- 4.7 s(-1)mM(-1); r2*(plasma) = 64.4 +/- 2.5 s(-1)mM(-1); 3.0 T: r1(saline) = 10.0 +/- 0.3 s(-1)mM(-1); r1(plasma) = 9.5 +/- 0.2 s(-1)mM(-1); r2(saline) = 62.3 +/- 3.7 s(-1)mM(-1); r2(plasma) = 65.2 +/- 1.8 s(-1)mM(-1); r2*(saline) = 57.0 +/- 4.7 s(-1)mM(-1); r2*(plasma) = 55.7 +/- 4.4 s(-1)mM(-1)). The dependence of relaxation rates on concentration in blood was nonlinear. Formulas from second-order polynomial fittings of the relaxation rates were calculated to characterize the relationship between R1(blood) and R2 (blood) with ferumoxytol.Conclusions: Ferumoxytol demonstrates strong longitudinal and transverse relaxivities. Awareness of the nonlinear relaxation behavior of ferumoxytol in blood is important for ferumoxytol-enhanced magnetic resonance imaging applications and for protocol optimization.