Optical imaging of propofol‐induced central respiratory depression in medulla–spinal cord preparations from newborn rats
Optical imaging of propofol‐induced central respiratory depression in medulla–spinal cord preparations from newborn rats
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DOI：
10.1111/j.1440-1681.2011.05480.x
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发表时间：
2011-03
影响因子：
2.9
通讯作者：
M. Kashiwagi;Y. Osaka;H. Onimaru;J. Takeda
中科院分区：
文献类型：
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作者：
M. Kashiwagi;Y. Osaka;H. Onimaru;J. Takeda
1. 异丙酚（2,6 -二异丙酚）是一种静脉麻醉剂，用于诱导和维持全身麻醉；它还能有效且剂量依赖性地抑制呼吸。本研究的目的是分析异丙酚诱导的吸气相关神经活动时空模式的变化，并通过光学成像技术研究GABAA受体的参与。
1. Propofol (2,6‐diisopropylphenol) is an intravenous anaesthetic used for the induction and maintenance of general anaesthesia; it also potently and dose‐dependently depresses respiration. The aim of the present study was to analyse propofol‐induced changes in spatiotemporal patterns of inspiratory‐related neural activity and to investigate the involvement of the GABAA receptor by using an optical imaging technique.