Pressure, Flow Rate and Operating Speed Characteristics of a Continuous Flow Left Ventricular Assist Device During Varying Speed Support
Pressure, Flow Rate and Operating Speed Characteristics of a Continuous Flow Left Ventricular Assist Device During Varying Speed Support
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DOI：
10.1109/access.2020.3009264
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发表时间：
2020-01-01
期刊：
影响因子：
3.9
通讯作者：
Bozkurt, Selim
中科院分区：
文献类型：
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作者：
Bozkurt, Selim
连续流左心室辅助装置的水力性能取决于其压头和流速关系。这些装置的水力特性通过在脉动环境中的压头和流速环来表示，因为它们被植入在左心室尖部和主动脉之间。尽管如此，恒速连续流左心室辅助装置支持会因患者体内血流改变而导致并发症。因此，已经提出了逐搏变速连续流左心室辅助装置支持算法，以在同步同脉或反脉模式下操作这些装置，这可以在循环系统中产生更多的生理血流。然而，在变速连续流左心室辅助装置支持期间，速度变化对压头和流速环路的影响仍不清楚。在这项研究中，利用数值模拟分析了连续流左心室辅助装置中同向脉动和反向脉动泵支持期间的压头、流量和运行速度关系。仿真结果表明，压头-流量-工作转速回路能更好地表达连续流左心辅助装置在变速心脏泵支持时的特性。此外，泵流速-操作速度和压头-操作速度图显示了心脏泵的动态行为，也包括速度。因此，了解速度、流速和泵压差之间的关系可能有助于开发新的逐搏操作模式，以改善连续流左心室辅助装置的支持。
Hydraulic performance of Continuous Flow Left Ventricular Assist Devices depends on their pressure head and flow rate relations. Hydraulic characteristics of these devices are expressed by pressure head and flow rate loops in a pulsatile environment as they are implanted between left ventricular apex and aorta. Nonetheless, constant speed Continuous Flow Left Ventricular Assist Device support causes complications due to altered blood flow in the patients' body. Therefore, beat-to-beat varying speed Continuous Flow Left Ventricular Assist Device support algorithms have been proposed to operate these devices in synchronized co-pulsating or counter-pulsating modes which can generate more physiological blood flow in the circulatory system. However, the effect of speed variation on the pressure head and flow rate loops remains unclear during varying speed Continuous Flow Left Ventricular Assist Device support. In this study, pressure head, flow rate and operating speed relations during co-pulsating and counter-pulsating pump support in a Continuous Flow Left Ventricular Assist Device were analyzed utilizing numerical simulations. Simulation results show that pressure head - flow rate - operating speed loops can express Continuous Flow Left Ventricular Assist Device characteristics better during varying speed heart pump support. Moreover, pump flow rate - operating speed and pressure head - operating speed diagrams show the dynamic behavior of a heart pump, including also the speed. Therefore, understanding the relationship between speed, flow rate and the pressure difference across a pump may help to develop novel beat-to-beat operating modes to improve Continuous Flow Left Ventricular Assist Device support.