Mucins and immune reactions to mucins in ulcerative colitis
Mucins and immune reactions to mucins in ulcerative colitis
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DOI：
10.1159/000051907
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发表时间：
2001-01-01
期刊：
影响因子：
3.2
通讯作者：
Imai, K
中科院分区：
文献类型：
--
作者：
Hayashi, T;Ishida, T;Imai, K
溃疡性结肠炎(UC)是一种病因不明的炎症性肠病。粘蛋白主要由杯状细胞产生，保护结肠细胞免受各种压力的影响。粘蛋白的质量或数量的改变可能是疾病的原因。另一个可能的原因是对联合细胞的免疫反应。UC患者血清中检测到抗MUC1抗体。抗体通过抗体依赖的细胞介导的细胞毒作用破坏结肠细胞。我们就粘蛋白、体液免疫和细胞免疫在UC发病机制中的意义作一综述。版权所有(C)2001 S.Karger AG，巴塞尔。
Ulcerative colitis (UC) is an inflammatory bower disease of undetermined etiology. Mucins, mainly produced by goblet cells, protect colon cells from various kinds of stress. Alteration in the quality or quantity of mucins may be the cause of the disease. Another possible cause is immune reactions to co ion ic cells. Anti-MUC1 antibodies were detected in the sera of patients with UC. Antibodies would destroy the colonic cells through antibody-dependent cell-mediated cytotoxicity. We reviewed the significance of mucins as well as humoral and cellular immunity in the pathogenesis of UC. Copyright (C) 2001 S. Karger AG, Basel.