Can SPME Fiber and Tenax Methods Predict the Bioavailability of Biotransformed Insecticides?
Can SPME Fiber and Tenax Methods Predict the Bioavailability of Biotransformed Insecticides?
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DOI：
10.1021/es2035174
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发表时间：
2012-02-21
影响因子：
11.4
通讯作者：
Lydy, Michael J.
中科院分区：
文献类型：
--
作者：
Harwood, Amanda D.;Landrum, Peter F.;Lydy, Michael J.
最近的研究认识到，化学技术，如固相微萃取（SPME）纤维和Tenax提取的能力，以预测生物利用度更有效地比详尽的化学提取沉积物相关的有机污染物。虽然使用这些技术的大多数研究都是研究传统化合物，如多氯联苯和多环芳烃，但这些方法很有可能适用于高毒性，快速生物转化的化合物，如拟除虫菊酯杀虫剂。目前的研究比较了两种技术的能力，以预测的生物利用度的氯菊酯和联苯菊酯的两种底栖无脊椎动物（蚯蚓variegatus和Havenia sp。）。此外，还探讨了两种技术应用的变化，特别是SPME纤维暴露的持续时间和条件以及Tenax浸提的持续时间。SPME纤维浓度与6和24 h Tenax浓度均强烈相关。SPME纤维浓度和6 h和24 h Tenax浸提物浓度与稳态下两种物种组织中的母体二氯苯菊酯和联苯菊酯浓度相关。两个种属的母体化合物组织浓度可通过单个拟除虫菊酯的单一关系进行预测。这证明了这些方法的潜在价值，以预测生物转化和应用到多个物种的化合物的生物利用度。
Recent studies recognize the ability of chemical techniques such as solid phase microextraction (SPME) fibers and Tenax extraction to predict bioavailability more effectively than exhaustive chemical extractions for sediment-associated organic contaminants. While the majority of research using these techniques studied legacy compounds such as PCBs and PAHs, there is great potential for these methods to work well for highly toxic, rapidly biotransformed compounds such as pyrethroid insecticides. The current study compared the ability of the two techniques to predict the bioavailability of permethrin and bifenthrin to two benthic invertebrates (Lumbriculus variegatus and Hexagenia sp.). In addition, variations in the application of the two techniques, specifically duration and conditions of exposure of the SPME fibers and duration of extraction with Tenax, were explored. The SPME fiber concentrations correlated strongly to both 6 and 24 h Tenax concentrations. The SPME fiber concentrations and 6 h and 24 h Tenax extractable concentrations correlated with both the parent permethrin and bifenthrin concentrations in the tissues of both species at steady state. Parent compound tissue concentrations for both species could be predicted with a single relationship for individual pyrethroids. This demonstrated the potential value of these methods to predict the bioavailability of compounds subject to biotransformation and application to multiple species.