Risk Factors of Transfusion in Anemia of Very Low Birth Weight Infants
Risk Factors of Transfusion in Anemia of Very Low Birth Weight Infants
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DOI：
10.3349/ymj.2013.54.2.366
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发表时间：
2013-03-01
影响因子：
2.4
通讯作者：
Sin, Jong Beom
中科院分区：
文献类型：
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作者：
Jeon, Ga Won;Sin, Jong Beom
目的：早产儿贫血是常见的早产儿，红细胞输注仍然是治疗的选择。在这项研究中，我们试图评估早产儿贫血的特点和危险因素，并提出减少贫血和多次输血的方法。材料与方法：体重小于1500 g的早产儿（2008年5月至2009年5月）根据是否接受RBC输注分为两组（输注组和非输注组）。分析血红蛋白（Hb）浓度、放血失血量和红细胞输注量。分析贫血和红细胞输注的危险因素。结果：50例存活婴儿入组本研究：输血组39例，非输血组11例。Hb浓度在8周内逐渐下降。输血组胎龄和出生体重较非输血组小，支气管肺发育不良和败血症发生率较高，完全喂养延迟，肠外营养和住院天数延长，静脉切开失血量大于非输血组。结论：早产儿贫血与实验室失血量增加、出生体重下降、肠外营养延长和体重增加延迟相关。因此，减少实验室放血损失和肠外营养，以及改善体重增加，可能是有益的早产儿贫血。
Purpose: Anemia of prematurity is frequent in preterm infants, for which red blood cell (RBC) transfusion remains the treatment of choice. In this study, we attempted to evaluate the characteristics and risk factors of anemia of prematurity, and suggest ways to reduce anemia and the need for multiple transfusions. Materials and Methods: Preterm infants weighing less than 1500 g (May 2008-May 2009) were divided into two groups depending on whether they received RBC transfusions (transfusion group and non transfusion group). Hemoglobin (Hb) concentration, phlebotomy blood loss, and the amount of RBC transfusion were analyzed. Risk factors of anemia and RBC transfusions were analyzed. Results: Fifty infants that survived were enrolled in the present study: 39 in the transfusion group and 11 in the non transfusion group. Hb concentrations gradually decreased by eight weeks. In the transfusion group, gestational age and birth weight were smaller, bronchopulmonary dysplasia and sepsis were more frequent, full feeding was delayed, parenteral nutrition and days spent in the hospital were prolonged, and phlebotomy blood loss was greater than that in the non transfusion group. Conclusion: Anemia of prematurity was correlated with increased laboratory blood loss, decreased birth weight, prolonged parenteral nutrition, and delayed body weight gain. Accordingly, reducing laboratory phlebotomy loss and parenteral nutrition, as well as improving body weight gain, may be beneficial to infants with anemia of prematurity.