Persistent, comorbid pain and anxiety can be uncoupled in a mouse model
Persistent, comorbid pain and anxiety can be uncoupled in a mouse model
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在小鼠模型中，持续的共病疼痛和焦虑可以被解开
DOI：
10.1016/j.physbeh.2015.07.004
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发表时间：
2015-11-01
影响因子：
2.9
通讯作者：
Zhang, Yu-Qiu
中科院分区：
文献类型：
--
作者：
Liu, Yan;Yang, Liu;Zhang, Yu-Qiu
临床上，疼痛和焦虑经常并存。然而，在动物研究中，这两种条件的相互作用是有限的并且是矛盾的。在这项研究中，我们将社交失败（SD）压力与弗氏佐剂（CFA）诱导的持续性炎症疼痛结合起来，研究两种小鼠品系的焦虑样行为和伤害性行为之间的相互关系。 C57BL/6J小鼠经受持续10天的CD-1小鼠反复攻击性SD应激，在社交互动（SI）测试中表现出显着的社交回避行为，这被认为代表了焦虑症状。这些小鼠还在高架十字迷宫（EPM）和开放场（OF）测试中表现出类似焦虑的行为。与 C57BL/6J 小鼠相比，FVB/NJNju 小鼠表现出较少的基础社会接触，但它们对 10 天 SD 应激的行为反应更具弹性。两种品系的 CFA 炎症小鼠均表现出强烈的机械异常性疼痛和热痛觉过敏，但在 CFA 炎症后 10 天没有出现明显的社交回避和焦虑样行为。有趣的是，在大多数测试中，暴露于 SD 应激的 CFA 炎症小鼠并没有伴随疼痛和焦虑样行为的恶化。相比之下，SD 应激引起的社交回避与 CFA 炎症疼痛相结合可显着拮抗。这些发现表明，在合并症动物模型中，持续的炎症性疼痛和 SD 应激引起的焦虑不一定会相互加剧。 (C) 2015 爱思唯尔公司保留所有权利。
Clinically, pain and anxiety frequently coexist; however, these two conditions' interaction is limited and contradictory in animal studies. In this study, we combined social defeat (SD) stress with Freund's adjuvant (CFA)-induced persistent inflammatory pain to investigate the reciprocal relationship between anxiety-like and nociceptive behaviors in two mouse strains. C57BL/6J mice subjected to the 10-day period of SD stress by repeated CD-1 mice aggression exhibited significant social interaction avoidance behaviors in the social interaction (SI) test, which is believed to represent the symptoms of anxiety. These mice also displayed anxiety-like behaviors in elevated plus maze (EPM) and open field (OF) tests. Compared to C57BL/6J mice, FVB/NJNju mice showed less basal social contact, but their behavioral responses to 10-day SD stress were more resilient. CFA-inflammatory mice showed robust mechanical allodynia and thermal hyperalgesia in both strains, but did not develop obvious social avoidance and anxiety-like behaviors 10 days after CFA-inflammation. Interestingly, CFA-inflammatory mice exposed to SD stress were not accompanied by a worsening of pain and anxiety-like behaviors in most tests. In contrast, the SD stress-induced social avoidance was significantly antagonized by combining with CFA-inflammatory pain. These findings suggest that persistent inflammatory pain and SD stress-induced anxiety may not necessarily exacerbate one another in animal models of comorbidity. (C) 2015 Elsevier Inc All rights reserved.