ALKALOIDS OF ACRONYCHIA BAUERI SCHOTT .2. ISOLATION OF ALKALOIDS AND A STUDY OF ANTITUMOR AND OTHER BIOLOGICAL PROPERTIES OF ACRONYCINE
ALKALOIDS OF ACRONYCHIA BAUERI SCHOTT .2. ISOLATION OF ALKALOIDS AND A STUDY OF ANTITUMOR AND OTHER BIOLOGICAL PROPERTIES OF ACRONYCINE
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DOI：
10.1002/jps.2600550803
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发表时间：
1966-01-01
影响因子：
3.8
通讯作者：
BODER, GB
中科院分区：
文献类型：
--
作者：
SVOBODA, GH;POORE, GA;BODER, GB
利用差示提取技术对澳大利亚植物Acronychia Baueri Schott（Bauerella australiana Borzi）的树皮进行检查，导致分离出三萜羽扇豆醇和生物碱黑胡椒碱、acronycine和去甲黑胡椒定。与从乙醚提取物中获得的粗生物碱混合物相关的实验抗肿瘤活性已被证明归因于首环素。本文给出了实验证据，表明阿克柔霉素具有迄今为止在这些实验室分离的任何生物碱中最广泛的抗肿瘤谱。由于其与目前使用的任何抗肿瘤药物在化学上不相关，因此它代表了寻找有效用于人类肿瘤化疗管理的药物的新线索。
Utilizing a differential extraction technique for the examination of the bark of the Australian plant Acronychia Baueri Schott (Bauerella australiana Borzi), has resulted in the isolation of the triterpene lupeol and the alkaloids melicopine, acronycine, and normelicopidine. The experimental antitumor activity associated with the crude alkaloidal mixture obtained from the ether extract has been shown to be attributable to acronycine. Experimental evidence is herein given, showing acronycine to have the broadest antitumor spectrum of any alkaloid isolated to date in these laboratories. By virtue of its being chemically unrelated to any of the presently utilized antitumor agents it represents a new lead in the search for agents effective in the chemotherapeutic management of human neoplasms.