Effects of Glutamine and Alanine Supplementation on Adiposity, Plasma Lipid Profile, and Adipokines of Rats Submitted to Resistance Training
Effects of Glutamine and Alanine Supplementation on Adiposity, Plasma Lipid Profile, and Adipokines of Rats Submitted to Resistance Training
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DOI：
10.1080/19390211.2018.1472716
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发表时间：
2019-11-02
影响因子：
2.5
通讯作者：
Tirapegui, Julio
中科院分区：
文献类型：
--
作者：
Coqueiro, Audrey Yule;Raizel, Raquel;Tirapegui, Julio
谷氨酰胺和丙氨酸是脂肪生成的，可以阻止阻力训练（RT）在减少肥胖和调节血脂方面的作用。因此，我们的目的是研究RT和谷氨酰胺和丙氨酸补充，在其自由或共轭形式，对相对附睾脂肪组织（EAT）和棕色脂肪组织（BAT）的重量，血脂谱，和脂肪因子在EAT。将30只2月龄Wistar大鼠分为5组：对照组（CTRL）、训练组（TRN）、训练后补充丙氨酸（ALA）组、谷氨酰胺+丙氨酸（GLN+ALA）组和L-丙氨酰-L-谷氨酰胺（DIP）组。训练组进行了为期八周的爬梯运动，逐步增加负荷。在过去的21？天的训练。与对照组相比，TRN组的摄食量和体重增加减少。RT还降低了相对EAT和BAT重量，而补充剂，特别是ALA，增加了脂肪组织质量。RT降低了总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-c）（TRN vs. CTRL），而谷氨酰胺和丙氨酸补充增加了TC和LDL-c，削弱了体育锻炼对血脂的调节。RT不影响EAT中脂肪因子的浓度，但DIP补充增加了白细胞介素-（IL-）6和IL-10。总之，RT减少肥胖和调制血脂谱，而谷氨酰胺和丙氨酸补充增加肥胖和受损的血脂谱，但增加抗炎细胞因子IL-6和IL-10的浓度在EAT。
Glutamine and alanine are lipogenic and could prevent the effects of resistance training (RT) in reducing adiposity and modulating lipid profile. Thus, we aimed to investigate the effects of RT and glutamine and alanine supplementation, in their free or conjugated form, on relative epididymal adipose tissue (EAT) and brown adipose tissue (BAT) weight, plasma lipid profile, and adipokines in EAT. Thirty Wistar rats, aged two months, were distributed into five groups: control (CTRL), trained (TRN), trained and supplemented with alanine (ALA), glutamine and alanine in their free form (GLN+ALA), or L-alanyl-L-glutamine (DIP). Trained groups underwent a ladder-climbing exercise for eight weeks, with progressive load increase. Supplementations were offered in a solution with a concentration of 4% in the last 21?days of training. Food consumption and body weight gain were decreased in the TRN group compared with CTRL. RT also reduced relative EAT and BAT weight, while supplementations, especially with ALA, increased adipose tissue mass. RT reduced total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c) (TRN vs. CTRL), whereas glutamine and alanine supplementation increased TC and LDL-c, impairing lipid profile modulation by physical exercise. RT did not affect the concentrations of adipokines in EAT, but DIP supplementation increased interleukin- (IL-) 6 and IL-10. In conclusion, RT reduced adiposity and modulated lipid profile, whereas glutamine and alanine supplementation increased adiposity and impaired lipid profile but increased the concentration of the anti-inflammatory cytokines IL-6 and IL-10 in EAT.